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CP Test 2 > B4-092 Lipoprotein Structure and Metabolism > Flashcards

B4-092 Lipoprotein Structure and Metabolism Flashcards

1
Q

degrades TGs remaining in LDL and chylomicron remnants

A

hepatic lipase

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2
Q

apoA-1 is found on

A

HDLs

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3
Q

activates LCAT

A

apoA1

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4
Q

apoB-100 is found on

A

LDL, VLDLs

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5
Q

binds LDL receptor

A

ApoB-100

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6
Q

ApoB-48 is found on

A

chylomicrons

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7
Q

mediates chylomicron secretion into lymphatics

A

apoB-48
apoE

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8
Q

ApoC-II is found on

A

chylomicrons, VLDL, HDL

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9
Q

lipoprotein lipase cofactor that catalyzes cleavage

A

apoC-II

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10
Q

apoE is found on

A

chylomicrons
VLDL
HDL

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11
Q

degrades TG in circulating chylomicrons and VLDL

A

lipoprotein lipase

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12
Q

degrades TGs remaining in IDL and chylomicron remnants

A

hepatic triglyceride lipase

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13
Q

catalyzes esterification of 2/3 plasma cholesterol

A

LCAT

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14
Q
  • regulation of LDL levels
  • redistribution of cholesterol
  • utilization of cholesterol
A

LDL receptors

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15
Q
  • uptake of cholesterol loaded chylomicron remnants and HDL
  • delivery of cholesterol to liver for excretion
A

LDL receptor related protein

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16
Q

selective uptake of cholesteryl esters

A

scavenger receptor

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17
Q
  • delivers dietary TGs to peripheral tissues
  • secreted by intestinal epithelial cells
A

chylomicrons

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18
Q

delivers cholesterol to liver in the form of chylomicron remnants

A

chylomicrons

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19
Q
  • delivers hepatic TGs to peripheral tissues
  • secreted by liver
A

VLDL

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20
Q
  • delivers TGs and cholesterol to liver
  • formed from degradation of VLDL
A

IDL

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21
Q
  • delivers hepatic cholesterol to peripheral tissues
  • formed by hepatic lipase modification of IDL in the liver and peripheral tissue
A

LDL

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22
Q

taken up by target cells via receptor mediated endocytosis

A

LDL

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23
Q
  • mediates reverse cholesterol transport from peripheral tissues to liver
  • secreted from both liver and intestine
A

HDL

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24
Q

plasma HDL is [….] related to risk of CVD

A

inversely

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25
Q

elevated LDL is a major risk for

A

atherosclerosis

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26
Q

LDL not taken up by hepatic LDL receptors migrates into

A

vascular intima

27
Q

oxidized LDL accumulates in foam cells and can damage intima via

A

foam cell necrosis

28
Q
  • caused by hepatic overproduction of VLDL
  • high TG
A

primary hyper triglyceridemia

29
Q

caused by absent or defective LDL receptors
or defective apoB-100 receptors

A

hypercholesterolemia

30
Q

high cholesterol with normal TG

A

primary hypercholesterolemia

31
Q
  • accelerated atherosclerosis
  • xanthomas
A

hypercholesterolemia

32
Q
  • defects in apoE
  • increased chylomicrons and IDL-like particles
A

dysbetalipoproteinemia

33
Q
  • common disorder
  • often with obesity, hyperinsulinemia, glucose intolerance, HTN
A

familial combined hyperlipidemia

34
Q

complex lipid profiles, elevated total cholesterol
HDL often reduced

A

mixed hyperlipidemias

35
Q

caused by defective ABCA1

A

tangier disease

36
Q

statins

A

HMG CoA reductase inhibitors

37
Q

efflux cholesterol across the canalicular membrane

A

ABCG5/G8

38
Q

transport of bile acids into canaliculi

A

ABCB11

39
Q

phospholipid floppase

A

ABCB4

40
Q

tangier is caused by defective

A

ABCA1

41
Q

what happens when ABCA1 is defective

A

cholesterol accumulates in cells because its not available to efflux it to HDL

42
Q

reduced HDL, LDL and total cholesterol is characteristic of

A

Tangier disease

43
Q

major apolipoprotein of HDL

A

apoA-1

44
Q

cholesterol efflux from macrophages

A

ABCA1

45
Q

phospholipid floppase in canalicular membranes of hepatocytes

A

ABCB4

46
Q

bile salt export pump in canalicular membrane of hepatocytes

A

ABCB11

47
Q

cholesterol efflux from hepatocytes

A

ABCG5/G8

48
Q

dysfunction ApoA-1 will result in

A

decreased HDL
no reverse pathway

49
Q

dysfuctional ApoA-1 is a major risk factor for

A

CVD

50
Q
  • produced by enterocytes
  • carry dietary TGs to liver and periphery
A

chylomicrons

51
Q

ligand for LDL receptor

A

ApoB-100

52
Q

activates LCAT

A

ApoA-1

53
Q

activates lipoprotein lipase

A

ApoC-II

54
Q

ligand for SR-B1

A

apoE

55
Q

acquires free cholesterol and transports it back to the liver

A

HDL

56
Q

carry TGs from intestine

A

chylomicrons

57
Q

carry TGs from liver

A

VLDL

58
Q

transports cholesterol to peripheral tissues and potentially deposits some in capillaries

A

LDL

59
Q

ApoA-1 activates

A

LCAT

60
Q

apoB-100 is a ligand for

A

LDL receptor

61
Q

apoE is a ligand for

A

LDL receptor
SR-B1

62
Q

contains mainly cholesterol esters

A

HDL

63
Q
  • produced by liver
  • important for transport of liver derived TGs
A

VLDL

64
Q

made from VLDL loosing fatty acids and apolipoproteins

A

LDL

CP Test 2 (16 decks)

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