B4-014 Drug-Drug Interactions

Question 1

two drugs, when taken together, have and additive or canceling effect

Answer 1

pharmacodynamics

Question 2

• when two drugs are taken together, one drug induces significant changes in the metabolism/elimination of the other
• increases or decreases concentration

Answer 2

pharmacokinetics

Question 3

which two proteins are most commonly involved in pharmacokinetic interactions?

Answer 3

CYP3A4 and P-glycoproteins

Question 4

two main types of DDI

Answer 4

drug drug
herb drug

Question 5

the drug that causes the DDI is called

Answer 5

perpetrator drug

Question 6

the drug which gets affected by the perpetrator drug is

Answer 6

victim drug

Question 7

the mechanism where two drugs interact leading to an additive effect or canceling each other’s activities

Answer 7

pharmacodynamic

Question 8

the mechanism where perpetrator drug changes ADME of the victim drug

Answer 8

pharmacokinetic

Question 9

two major types of proteins involved in DDI

Answer 9

CPY450 and drug transporter

Question 10

major enzyme in pharmacokinetic DDI is

Answer 10

CYP3A4/5

Question 11

the major drug transporter involved in pharmacokinetic DDI is

Answer 11

p-glycoprotein