B4-071 Vasculitides

Question 1

most commonly affects branches of carotid artery

Answer 1

giant cell arterits

Question 2

most common form of vasculitis among elderly and adults in US and europe

Answer 2

giant cell arteritis

Question 3

headaches
jaw claudication
ischemic optic neuropathy

Answer 3

giant cell arteritis

Question 4

• infiltrate of T cells and macrophages
• multinucleated giant cells

Answer 4

giant cell arteritis

Question 5

ocular symptoms

Answer 5

giant cell arteritis

Question 6

pulseless disease

Answer 6

takayasu arteritis

Question 7

marked weakening of pulses in upper extremities

Answer 7

takayasu arteritis

Question 8

thickening and narrowing of aortic arch and proximal great vessels

Answer 8

takayasu arteritis

Question 9

• large vessel vasculitis
• patient is under 50

Answer 9

takayasu arteritis

Question 10

• large vessel vasculitis
• patient is over 50

Answer 10

giant cell arteritis

Question 11

1/3 of patient have hepatitis B

Answer 11

polyarteritis nodosa

Question 12

• involves renal and visceral vessels
• spares pulmonary circulation

Answer 12

polyarteritis nodosa

Question 13

string of pearls

Answer 13

polyarteritis nodosa

Question 14

different stages of activity coexist in the same vessel

Answer 14

polyarteritis nodosa

Question 15

• rapidly accelerating hypertension
• abdominal pain
• bloody stools

Answer 15

polyarteritis nodosa

Question 16

self limited illness of infancy and childhood

Answer 16

kawasaki disease

Question 17

children under 4

Answer 17

kawasaki disease

Question 18

• conjunctival and oral erythema and blistering
• edema of hands and feet
• erythema of palms and soles

Answer 18

kawasaki disease

Question 19

treat with IV Ig and aspirin

Answer 19

kawasaki

Question 20

• affects capillaries, arterioles and venules
• all lesion tend to be of same age

Answer 20

microscopic polyangitis

Question 21

affects skin, mucous membranes, lungs, brain, heart, GI, kidney, muscle

Answer 21

microscopic polyangitis

Question 22

• necrotizing glomerulonephritis
• pulmonary capillaritis

Answer 22

microscopic polyangitis

Question 23

MPO ANCAs

2

Answer 23

microscopic polyangitis
Churg-Strauss

Question 24

• hemoptysis
• hematuria/proteinuria
• bowel pain
• palpable purpura

Answer 24

microscopic polyangitis

Question 25

extravasation of RBCs
pauci-immune injury

Answer 25

microscopic polyangitis

Question 26

acute necrotizing granulomas of respiratory tract

Answer 26

GPA

Question 27

focal necrotizing, often crescentic glomerulonephritis

Answer 27

GPA

Question 28

PR3 ANCAs

Answer 28

GPA

Question 29

• focal necrotizing vasculitis
• necrotizing granulomas in lung and upper airway
• necrotizing glomerulonephritis

Answer 29

GPA

Question 30

bilateral pneumonitis with nodules and cavitary lesions

Answer 30

GPA

Question 31

chronic sinusitis

Answer 31

GPA

Question 32

mucosal ulcerations of nasopharynx

Answer 32

GPA

Question 33

similar to GPA without nasopharyngeal involvement

Answer 33

microscopic polyangitis

Question 34

• asthma
• allergic rhinitis
• peripheral eosinophilia

Answer 34

churg-strauss

Question 35

palpable purpura
GI bleeding

Answer 35

churg-strauss

Question 36

both granulomas and eosinophils

Answer 36

churg-strauss

Question 37

occurs in heavy smokers

Answer 37

thromboangitis obliterans
Buerger disease

Question 38

may cause gangrene/amputaion of digits

Answer 38

Buerger disease

Question 39

raynaud phenomenon

Answer 39

Buerger disease

Question 40

• small microabscesses
• extends into contiguous veins and nerves

Answer 40

Buergers

Question 41

linear deposits of IgG and C3 in GBM

Answer 41

goodpastures

Question 42

pulmonary hemorrhage associated with renal failure

Answer 42

goodpastures

Question 43

treatment for goodpastures

Answer 43

plasmapheresis

Question 44

• purpuric skin lesions-extensor surfaces of arms, legs, buttocks
• abdominal pain
• intestinal bleeding
• arthralgias

Answer 44

Henoch-schonlein

Question 45

IgA deposits

Answer 45

Henoch-Schonlein

Question 46

• IgG-IgM complexes
• cutaneous vasculitis
• synovitis

Answer 46

mixed cryoglobulinemia

Question 47

associated with hepatitis C

Answer 47

mixed cryoglobulinemia