B4-069 Cardiomyopathies Flashcards
most common cardiomyopathy
dilated
leads to systolic dysfunction
dilated
familial dilated cardiomyopathy is caused by a mutation in what protein?
titin
heart failure
S3 sound
sytolic regurgitant murmur
dilated cardiomyopathy
balloon appearance of heart on CXR
dilated cardiomyopathy
caused by mutations in myosin binding protein C and beta myosin heavy chains
hypertrophic cardiomyopathy
causes syncope during exercise, may lead to SCD
hypertrophic cardiomyopathy
S4 sound
systolic murmur
maybe mitral regurg
hypertrophic cardiomyopathy
cause diastolic dysfunction
2
hypertrophic cardiomyopathy
retrictive cardiomyopathy
eccentric hypertrophy
dilated cardiomyopathy
concentric hypertrophy
septal predominance
hypertrophic cardiomyopathy
most common genetic heart disease
most frequent cause of sudden cardiac death in young people
hypertrophic
- globoid
- markedly enlarged
dilated cardiomyopathy
strong alcohol use association
dilated cardiomyopathy
excess catecholamines
pheochromocytoma
dilated cardiomyopathy
subendocardial scars
mural thrombi
dilated cardiomyopathy
ejection fraction less than 25%
dilated cardiomyopathy
massive myocardial hypertrophy without ventricular dilation
hypertrophic cardiomyopathy
massive myocyte hypertrophy
haphazard disarray of bundles of myocytes
hypertrophic cardiomyopathy
cavities are not dilated
myocardium largely unremarkable
restrictive cardiomyopathy
name that restrictive cardiomyopathy
- children and YA
- linked to nutritional deficiencies and parasitic infections
- most common form worldwide
endomyocardial fibrosis
name that restrictive cardiomyopathy
- large mural thrombi
- peripheral eosinophilia
- associated with PDGFR
loeffler endomyocarditis
- fibroelastic thickening involving LV
- most common in first 2 years of life
- genetic
endocardial fibroelastosis
non-caseating, non-necrotizing granulomas
sarcoidosis
restrictive
- autosomal disorder
- causes right sided HF and rhythm disturbances
- massive fatty infiltration and focal fibrosis
arrhythmogenic cardiomyopathy
most common viral causes of myocarditis in US
- coxsackie
- CMV
- HIV
- influenza
non viral causes of myocarditis
- T. cruzi
- Trichinosis
- Toxoplasmosis
- Lyme
- Diptheria
- interstitial inflammatory infiltrate
- diffuse, mononuclear lymphocytic infiltrate
myocarditis
hypersensitivity myocarditis is characterized by what pathologic finding?
eosinophils
associated with pregnancy
dilated cardiomyopathy
what inheritance pattern is associated with HCM
autosomal dominant
stiff, non compliant myocardium
restrictive cardiomyopathy
amyloidosis causes what kind of cardiomyopathy?
restrictive
increased interstitial fibrosis due to radiation causes
restrictive cardiomyopathy
cobalts
anthracyclines
cocaine
cyclophosphamide
are associated with
dilated cardiomyopathy
ejection fraction between 50-80%
hypertrophic cardiomyopathy
- fatal condition
- multiple non-caseating granulomas
- multinucleated giant cells
- ventricular arrhythmia or heart block
giant cell myocarditis
most common identifiable cause of dilated cardiomyopathy in US and Europe
alcholic use disorder cardiomyopathy
correlated to total lifetime dose of ethanol
degree of myocardial damage
can alcohol abstinence reverse cardiomyopathy?
only in early stages
trypanosomes
myocarditis due to chagas
can occur in late pregnancy or up to a few months postpartum
peripartum cardiomyopathy
can present one month to one year or more after termination of therapy
doxorubicin induced heart failure
chemotherapy agent that can cause cardiomyopathy
doxorubicin
LVH without indentifiable cause
HCM
