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CP Test 2 > B4-020 Cell Biology and Histology of the Vascular System > Flashcards

B4-020 Cell Biology and Histology of the Vascular System Flashcards

1
Q

walls of ateries

A
  1. tunica intima (innermost)
  2. tunica media
  3. tunica externa (outermost)
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2
Q

lining of endothelial cells, subendothelian basement membrane and loose connective tissue, internal elastic lamina

A

tunica intima

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3
Q

concentric layers of smooth muscle, collagen fibers, external elastic lamina

A

tunica media

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4
Q

connective tissue

A

tunica externa

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5
Q

have many elastic lamella in the tunica media

A

large arteries

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6
Q

prominent internal elastic lamina

A

muscular arteries

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7
Q
  • major determinants of systolic blood pressure
  • regulate vascular tone
A

arterioles

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8
Q

2-5 concentric layers of vascular smooth muscle in tunica media

A

arterioles

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9
Q
A

large artery

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10
Q
A

medium/muscular artery

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11
Q
A

arteriole

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12
Q

thin tubes consisting of only basement membrane

A

capillary

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13
Q

permit the passage of 1 RBC at a time

A

capillary

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14
Q

3 types of capillaries

A
  • continuous
  • fenestrated
  • discontinous
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15
Q

continous capillaries can be found in what tissues

A

muscle, brain, thymus, lung

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16
Q

fenestrated capillaries can be found in what tissue

A

intestines, kidneys

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17
Q

discontinuous capillaries can be found in what tissues

A

liver, speen, bone marrow

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18
Q

what type of capillary requires vesicles?

A

continuous

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19
Q
A

continous capillary

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20
Q
A

fenestrated capillary

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21
Q

caveolae

A

transport vesicle

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22
Q
  • contractile cells surround capillaries
  • thought to regulate blood flow
  • role in angiogenesis
A

pericytes

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23
Q

loss of pericyte function in the CNS causes

A

increased permeability of blood-brain barrier

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24
Q

preferred site of diapedesis

A

veins

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25
Q

find: lymphatic vessel, venules, & arterioles

A
26
Q

veins have […] to prevent the reflux of blood

A

valves

27
Q
  • distinction between t. media and t. externa often unclear
  • t. media thinner
A

veins

28
Q

how to risk factors lead to the progression of atherosclerosis and CVD?

A

cause oxidative stress –> endothelial dysfunction –> reduced NO bioavailability

29
Q

lack tight junctions

A

lymphatic epithelial cells

30
Q
A

lymphatic vessel

31
Q
A

lymphatic vessel with valve

32
Q

creation of new vascular network

A

vasculogenesis

33
Q

sprouting from exisiting network

A

angiogenesis

34
Q

vasculogenesis and angiogenesis require

A

VEGF

35
Q

key mediator of vessel growth

A

hypoxia

36
Q

EPO and VEGF lead to

A

increased oxygen delivery

37
Q

EPO/IGF2 and GLUT allow for

A

oxygen deprivation survival

38
Q

targets VEGF, EPO, GLUT

A

HIF

39
Q
A
40
Q

required for both vasculogenesis and angiogenesis

A

VEGF

41
Q

creates new vessels from endothelial precursor cells

A

vasculogenesis

42
Q

creates new vessel via sprouting

A

angiogensis

43
Q

breakdown of the vessels basal lamina is necessary for

A

angiogenesis

44
Q

hemodynamic shear forces are minimized in

A

post capillary venules

45
Q

resemble continous capillaries with a wider lumen
do not have fenestrae

A

postcapillary venules

46
Q

preferred site for leukocyte diapedesis

A

postcapillary venule

47
Q

elastic lamella in tunica media

A

conducting arteries

48
Q

internal elastic membrane is prominent

A

muscular arteries

49
Q

elastic walls distend during systole and recoil during diastole so continous flow results

A

conducting arteries

50
Q

longitudinal smooth muscle bundles in the adventitia and transverse smooth muscle in media

A

large vein

51
Q

smooth muscle bundles run perpendicular to each other

A

large vein

52
Q

lymphatic vessels drain into ducts that drain into

A

large veins

53
Q

blood pressure is predominately regulated by

A

arterioles

54
Q

blood leaves the heart via

A

elastic arteries

55
Q

gas and nutrient exchange

A

capillaries

56
Q

no gaps in endothelium

A

continous capillaries

57
Q

lymph vessel drain into

A

lymphatic ducts

58
Q

supplies blood to walls of large vessels

A

vaso vasorum

59
Q

small endocytic vesicles and caveolae

A

continous capillaries

60
Q

discontinous basal lamina and large gaps in endothelium

A

sinusoidal capillaries

CP Test 2 (16 decks)

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