Dyslipidemia - Screening Flashcards
Who should be screened based on age for dyslipidemia?
3
Men 40+
Women 40+ or postmenopausal
What ethnic groups should be screened earlier?
2
south asian
indigenous
Which conditions should be screened at any age?
AAA
DM
HTN
Smoking
fam hx early CVD
fam hx dyslipidemia
CKD
Inflam diseases (RA, SLE, IBD etc)
Obesity
HIV infection
ED
COPD
hx HTN in pregnancy
What 5 things are used to screen for dyslipdemia?
- H&P
- lipid panel
- fasting glucose or A1C
- eGFR
- Lipoprotein(a)
Lipoprotein(a) should be done once in a lifeime with inital screening
What does elevated lipoprotein(a) indicate?
increased risk ASCVD even if LDL is well controlled
ASCVD = Atherosclerotic Cardiovascular Disease
What does an Lp(a) of 50+ indicate?
Lp(a) = lipoprotein A
high, need for earlier more intensive health behav mod and management
What are two optional screening tests?
ApoB
Urine albumin creatinine ration
When should you use the optional tool of urine ACR
3
eGFR<60
HTN
DM
Should dyslipidemia screening BW be done fasting or non fasting?
Non fasting except if triglycerides are known to be >4.5
Why is nonfasting screening important for most people
2
minimally changes relevant lipids
has no effect on apolipoprotein levels compared to fasting
Which element of the lipid panel is most impacted by not fasting?
triglycerides
not used much in risk assessment
What are apolipoproteins?
Proteins that bind to lipids to form lipoproteins
What role do apolipoproteins play in dyslipdemia
- Lipid metabolism
What is ApoB
and where is it found
- ApoB- found in LDL- marker for atherogenic particles
What is ApoA
and where is it found
Found in HDL
invovled in cholesterol transport
