Drugs to treat Inflammation Flashcards
What is the main function of glucocorticoids?
Inhibit Arachidonic Acid Release and metabolism
What is the main function of NSAIDs?
Blocking of COX1 and COX2
What is the main function of CysLT1 receptor antagonists?
block the effects of leukotrienes (bronchosopasm and vasodilation) LTC4 & LTD4
Leukotrienes are formed by the action of —–1—- on —–2—
5-lipoxygenease
Arachidonic Acid
Which of the 2 COX is ubiquitous and which is inducible?
COX1 in most cells
COX2 inflammatory cells and endothelium
what is the main reason phospholipid mediators do not have systemic functions?
metabolised in the lungs
Canabinoid receptors have anti-inflammatory functions. The one not expressed in neuronal tissues but in the periphery is
CB2
What are some of the effects mediated by CB1 and CB2
appetite stimulation/anti-nauseant analgesia sedation psychoactivity anti-inflammatory
what are some of the functions for NSAIDs
Anti-inflammatory
Analgesia
Antipyretic (paracetamol preferred tho)
how do NSAIDs achieve analgesia?
by blocking COX1 and COX2 there is an inhibition on their production of prostaglandins (to some extent prostacylcin too) that sensitise nerve endings to algesic agents
why is aspirin contraindicated in gout?
because it uses the same weak ion transporter that uric acid uses for excretion
why do NSAIDs cause gastrointestinal side-effects?
because it inhibits the production of PGE2 that is gastroprotective
what are the gastroprotective functions of PGE2
increased mucus secretion
reduces gastric acid secretion
promotes blood flow
promotes angiogenesis (revascularisation after injury)
why do NSAIDs increase bleeding time?
by blocking COX1 and COX2 there is an inhibition on their product thromboxane [TXA2] that induces platelet aggregation
What is the function of Prostaglandins (PGE2) in the kidney and how is it affected in NSAIDs use?
it causes relaxation of the mesangial cells of the kidney allowing for an increase in GFR
if COX1 is blocked tone is increased and there will be less GFR AND an increase in BP