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PSYC 462 > Drugs Only 2 > Flashcards

Drugs Only 2 Flashcards

1
Q

a drug that is a precursor to dopamine and quickly taken up; increases DA levels

A

L-DOPA

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2
Q

a drug that blocks TH, preventing synthesis of DA and NE

A

alpha-methyl-para-tyrosine (AMPT)

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3
Q

Drug that blocks VMAT, preventing DA and NE from being packaged, and making transmitter levels drop

A

Reserpine

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4
Q

a MAO inhibitor used to treat clinical depression

A

phenelzine

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5
Q

A COMT inhibitor that enhances the effectiveness of L-DOPA in treating Parkinson’s disease

A

tolcapone

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6
Q

drug that inhibits reuptake of all monoamines (DA, NE, 5-HT)

A

Cocaine

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7
Q

drugs that inhibit reuptake of both NE and 5-HT

A

tricyclic antidepressants

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8
Q

Drug that selectively inhibits reuptake of catecholamines

A

methylphenidate (ritalin)

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9
Q

a drug that selectively inhbits reuptake of NE transporters

A

strattera

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10
Q

drugs that reverse the DA/NE transporter so that molecules from inside the terminal are pushed out into the synapse

A

amphetamine

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11
Q

an agonist that sitmulate both D1 and D2 receptors causing behavioural activation similar to that seen with cocaine and amphetamine

A

apomorphine

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12
Q

an antagonist that blocks both D1-D2 receptors, reducing motivation and at higher doses, producing catalepsy

A

flupenthixol

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13
Q

an antagonist that has >1000x affinity for D2 like vs D1 receptors, but binds with D2, D3 and D4 with similar affinity

A

haloperidol

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14
Q

an alpha-1 receptor agonist

A

phenylephrine

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15
Q

an alpha-1 receptor antagonist

A

prazosin

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16
Q

alpha-2 receptor agonist that reduces NE release in both the brain and body, slowing heart rate

A

clonidine, guanfacine

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17
Q

an alpha-2 receptor antagonist that blocks both postsynaptic and autoreceptors, leading to an anxiogenic type response

A

yohimbine

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18
Q

an agonist for beta-1 or beta-2 receptors

A

isoproterenol

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19
Q

an antagonist for beta-1 or beta-2 receptors

A

propanolol

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20
Q

A nonselective antagonist for AMPA, Kainate and NMDA receptors

A

Kyunurenic acid

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21
Q

a competitive antagonist that blocks both AMPA and kainate receptors but not NMDA

A

NBQX

22
Q

A competitive antagonist for NMDA receptors that block glutamate from binding

A

AP-5/APV

23
Q

Drugs that block the NMDA channel when its open; independently of glutamate binding

A

phencyclidine, ketamine, MK-801

24
Q

an agonist for mGluR 4,6,7, and 8 autoreceptors, which suppress glutamate release

A

L-AP4

25
Q

GABA-A competitive agonist (at GABA binding site)

A

muscimol

26
Q

GABA-A competitive antagonist

A

bicuculline

27
Q

GABA-A non competitive antagonist that binds inside the channel pore

A

picrotoxin

28
Q

a benzodiazepine that is used for sleep but reduces sleep quality because REM sleep is reduced over the sleep cycle; GABA-A allosteric modulator

A

diazepam

29
Q

barbiturate; GABA-A allosteric modulator

A

phenobarbital

30
Q

a GABA-B receptor agonist used as a muscle relaxant and experimental treatment for alcoholism

A

baclofen

31
Q

a GABA-B receptor antagonist that is a convulsant and is primarily used for research

A

saclofen

32
Q

positive allosteric modulators of AMPA receptors

A

ampakines

33
Q

a drug that blocks 5-HT synthesis by irreversibly inhibiting tryptophan hydroxylase

A

para-chloro-phenyl-alanine (PCPA)

34
Q

a drug that acts like amphetamine; reverses monoamine transporters to shoot 5-HT out into the synapse; was prescribed for appetite suppression in obese patients but caused cardiovascular side effects

A

fenfluramine

35
Q

A recreational drug that acts on SERT with higher affinity than DAT and NET; can cause enhanced sensations and may be used as a therapeutic agent for PTSD

A

3,4-methylenedioxymethamphetamine (MDMA, ecstasy, molly)

36
Q

drug that blocks SERT and thus acts as an SSRI

A

fluoxetine

37
Q

full agonist of 5-HT1A

A

8-OH-DPAT

38
Q

partial agonist of 5-HT1A

A

buspirone

39
Q

a 5-HT1A receptor antagonist

A

WAY-100635

40
Q

a 5-HT2A agonist that is hallucinogenic and disrupts 5-HT’s natural filter in the visual cortex

A

DOI

41
Q

5-HT2A antagonist

A

ketanserin

42
Q

drug that blocks choline transporters, reducing the rate of ACh production

A

hemicholinium-3 (HC-3)

43
Q

a drug that causes persistent activation of nicotinic receptors

A

carbachol

44
Q

a nicotinic receptor agonist that is a muscle relaxant used in some surgical procedures; it is resistant to breakdown by AChE and causes depolarization block

A

succinylcholine

45
Q

a nicotinic receptor antagonist that blocks receptors in both the CNS and autonomic ganglia; used to treat nicotine poisoning

A

mecamylamine

46
Q

a nicotinic receptor antagonist that blocks muscle nicotinic receptors but as relatively little effect on central receptors due to its selectively for muscle receptor and low penetrance across the BBB; used as a hunting tool by indigenous peoples; causes paralysis by preventing muscle contracts facilitated by ACh

A

D-tubocurarine

47
Q

a drug that prevents ACh from affecting DA neurons in the VTA

A

chantix

48
Q

a muscarinic receptor agonist which is a parasympathomimetic agent; poisoning leads to exaggerated parasympathetic responses such as salivation, vomiting, diarrhea, urination etc.

A

pilocarpine

49
Q

muscarinic receptor antagonists

A

atropine, scopolamine

50
Q

selective neurotoxin for 5-HT

A

5.7-DHT

PSYC 462 (16 decks)

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