Drugs Only 2 Flashcards
a drug that is a precursor to dopamine and quickly taken up; increases DA levels
L-DOPA
a drug that blocks TH, preventing synthesis of DA and NE
alpha-methyl-para-tyrosine (AMPT)
Drug that blocks VMAT, preventing DA and NE from being packaged, and making transmitter levels drop
Reserpine
a MAO inhibitor used to treat clinical depression
phenelzine
A COMT inhibitor that enhances the effectiveness of L-DOPA in treating Parkinson’s disease
tolcapone
drug that inhibits reuptake of all monoamines (DA, NE, 5-HT)
Cocaine
drugs that inhibit reuptake of both NE and 5-HT
tricyclic antidepressants
Drug that selectively inhibits reuptake of catecholamines
methylphenidate (ritalin)
a drug that selectively inhbits reuptake of NE transporters
strattera
drugs that reverse the DA/NE transporter so that molecules from inside the terminal are pushed out into the synapse
amphetamine
an agonist that sitmulate both D1 and D2 receptors causing behavioural activation similar to that seen with cocaine and amphetamine
apomorphine
an antagonist that blocks both D1-D2 receptors, reducing motivation and at higher doses, producing catalepsy
flupenthixol
an antagonist that has >1000x affinity for D2 like vs D1 receptors, but binds with D2, D3 and D4 with similar affinity
haloperidol
an alpha-1 receptor agonist
phenylephrine
an alpha-1 receptor antagonist
prazosin
alpha-2 receptor agonist that reduces NE release in both the brain and body, slowing heart rate
clonidine, guanfacine
an alpha-2 receptor antagonist that blocks both postsynaptic and autoreceptors, leading to an anxiogenic type response
yohimbine
an agonist for beta-1 or beta-2 receptors
isoproterenol
an antagonist for beta-1 or beta-2 receptors
propanolol
A nonselective antagonist for AMPA, Kainate and NMDA receptors
Kyunurenic acid
a competitive antagonist that blocks both AMPA and kainate receptors but not NMDA
NBQX
A competitive antagonist for NMDA receptors that block glutamate from binding
AP-5/APV
Drugs that block the NMDA channel when its open; independently of glutamate binding
phencyclidine, ketamine, MK-801
an agonist for mGluR 4,6,7, and 8 autoreceptors, which suppress glutamate release
L-AP4
GABA-A competitive agonist (at GABA binding site)
muscimol
GABA-A competitive antagonist
bicuculline
GABA-A non competitive antagonist that binds inside the channel pore
picrotoxin
a benzodiazepine that is used for sleep but reduces sleep quality because REM sleep is reduced over the sleep cycle; GABA-A allosteric modulator
diazepam
barbiturate; GABA-A allosteric modulator
phenobarbital
a GABA-B receptor agonist used as a muscle relaxant and experimental treatment for alcoholism
baclofen
a GABA-B receptor antagonist that is a convulsant and is primarily used for research
saclofen
positive allosteric modulators of AMPA receptors
ampakines
a drug that blocks 5-HT synthesis by irreversibly inhibiting tryptophan hydroxylase
para-chloro-phenyl-alanine (PCPA)
a drug that acts like amphetamine; reverses monoamine transporters to shoot 5-HT out into the synapse; was prescribed for appetite suppression in obese patients but caused cardiovascular side effects
fenfluramine
A recreational drug that acts on SERT with higher affinity than DAT and NET; can cause enhanced sensations and may be used as a therapeutic agent for PTSD
3,4-methylenedioxymethamphetamine (MDMA, ecstasy, molly)
drug that blocks SERT and thus acts as an SSRI
fluoxetine
full agonist of 5-HT1A
8-OH-DPAT
partial agonist of 5-HT1A
buspirone
a 5-HT1A receptor antagonist
WAY-100635
a 5-HT2A agonist that is hallucinogenic and disrupts 5-HT’s natural filter in the visual cortex
DOI
5-HT2A antagonist
ketanserin
drug that blocks choline transporters, reducing the rate of ACh production
hemicholinium-3 (HC-3)
a drug that causes persistent activation of nicotinic receptors
carbachol
a nicotinic receptor agonist that is a muscle relaxant used in some surgical procedures; it is resistant to breakdown by AChE and causes depolarization block
succinylcholine
a nicotinic receptor antagonist that blocks receptors in both the CNS and autonomic ganglia; used to treat nicotine poisoning
mecamylamine
a nicotinic receptor antagonist that blocks muscle nicotinic receptors but as relatively little effect on central receptors due to its selectively for muscle receptor and low penetrance across the BBB; used as a hunting tool by indigenous peoples; causes paralysis by preventing muscle contracts facilitated by ACh
D-tubocurarine
a drug that prevents ACh from affecting DA neurons in the VTA
chantix
a muscarinic receptor agonist which is a parasympathomimetic agent; poisoning leads to exaggerated parasympathetic responses such as salivation, vomiting, diarrhea, urination etc.
pilocarpine
muscarinic receptor antagonists
atropine, scopolamine
selective neurotoxin for 5-HT
5.7-DHT
