Drugs And PNS Flashcards
What is the precursor for ach productjon
Choline and acetyl coA added
Which enzyme produces ach from choline and acetyl coA
Cholineacetyl transferase
What are the 2 types of nicotinic receptor
Neuronal : at the autonomic ganglia of both SNS and PNS
Muscle type: somatic Ns causing an EPP
Name things which happen due to agonists at the muscarinic receptor and Ach (PNS)
Constriction of pupils Bronchoconstriction Bradycardia Increase digestion Increased salivation Increased sweating Contraction of bladder Relaxation of rectum
What are agonists for the muscarinic ach receptor called
Parasympathomimitics
What are agonists for muscarinic receptor called
Parasympatholytics
How can agonists be used for glaucoma treatment
Can cause construction in pupil
How can salivation via muscarinic receptors be a treatment
Agonists when they bind cause salivation which helps xerostomia dry mouth
Why would muscarinic antagonists be used in eye surgery
To help dilate the pupil by stopping signalling at muscarinic receptor
Why do muscarinic antagonists parasymaptholytics help treat asthma
They cause bronchidilation
Which drugs would be used to treat travel sickness and why
Parasympatholytics
They decrease digestion / GI mobility
Which systems do nicotinic drugs affect
SNS , PNS and autonomic
Why don’t nicotinic agonists or antagonists get used at the PNS and SNS
Because they would stimulate or inhibit both the SNS and PNS systems which would cause confusion
Because they are found at autonomic ganglion
Why are muscle type nicotinic agonists called depolarisation blockers
They initially cause depolarisation because they mimic ach at nmj, but because they aren’t metabolised by achesterase these then paralyse the muscle and depolarisation is blocked
What are muscle type nicotinic antagonists called and why
Non depolarising blockers
They never cause initial depolarisation but cause hyperpolarisation stopping epp by blocking ach
