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Pharmacology > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

Which 2 monoamine Nts affect depression

A

5HT and nadr

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2
Q

Where is n adr produced in the brain

A

Locus (cell bodies)

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3
Q

Where is 5 HT produced

A

Raphe nuclei

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4
Q

Which 3 areas does 5HT and nadr from brain travel to

A

Cortex

Hypothalamus

Hippocampus

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5
Q

What is the pre cursor for 5HT at the raphe nuclei

A

Tryptophan

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6
Q

How is tryptophan converted to 5HT

A

Trp hydroxylase

This produced 5 HTP

5HTP decarboxylase converts it to

5HT

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7
Q

What is the full metabolism of nadr like

A

Nadr

Converted to

DOPEG via MAO and aldehyde dehydrogenase

From DOPEG to MHPG via catechol o methyl transferase

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8
Q

How is 5HT metabolised

A

Into aldehyde via MAO

Into 5H IAA

Via aldehyde dehydrogenase

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9
Q

Which line of 5HT receptors are inhibitory

A

5HT1

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10
Q

Which 5HT receptors are stimulatory and how

A

5HT2

They are gpcr which activate the Phospholipase system

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11
Q

which 5HT receptor is ligand ion channel receptor

A

5HT3

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12
Q

What is the auto receptor for nadr and also for 5HT

A

Nadr - A2

5HT - 5HT1B

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13
Q

What do autoreceptors at the cell bodies eg focus and the raphe nuclei do

A

Inhibit firing and release of nadr and 5HT

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14
Q

Which 5HT receptor is an auto receptor which inhibits firing from cell body and how

A

5HT1 a

Causes opening or K* channels which causes hyperpolarisation

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15
Q

Which reuptake transporters are used

A

High affinity reuptake transporters

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16
Q

Which 2 drugs suggested increased 5HT and nadr reduce depression

A

MAOI and reuptake inhibitors

17
Q

What is an issue with using MAOI to increase 5HT and nadr

A

Decreases the metabolism of DA and amines which then cause sympathomimetic effects like hypertension

18
Q

What are the 2 types of reuptake inhibitors

A

SSRI

Tricyclic antidepressants

19
Q

What do tricyclic inhibit reuptake of

A

Both 5HT and nadr

20
Q

What are 3 side effects of the tricyclic reuptake inhibitors

A

Muscarinic antagonists- can cause things like dry mouth

H1 antagonists - causes sedation

A1 antagonists - causes hypotension (loss of vasoconstriction)

21
Q

What is serotonin syndrome

A

Too much serotonin eg due to MAOI and SSRI can cause malignant hyperthermia (over heating)

22
Q

Why do antidepressants not work till few weeks after

A

1- auto receptors need time to desensitise to start to increase firing from cell body to release 5HT and nadr

2- synaptic plasticity via 5HT takes time which then causes normal mood

Pharmacology (24 decks)

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