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OU Practice Fall 2018 > Drugs 5:19-36 > Flashcards

Drugs 5:19-36 Flashcards

1
Q

alosetron brand name and uses

A
  • Lotronex

- irritable bowel syndrome with diarrhea

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2
Q

alosetron dosing

A
  • 0.5 mg twice daily

- decrease to 0.5 mg daily if constipation; max 1 mg bid

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3
Q

eluxadoline brand name and uses

A
  • Viberzi

- irritable bowel syndrome with diarrhea

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4
Q

eluxadoline dosing

A

75 - 100 mg bid with food; dosage dependent on patient characteristics / drug interactions

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5
Q

atropine / hyoscyamine / scopolamine / phenobarbital brand name and uses

A
  • Donnatal
  • Donnatal Extentabs
  • irritable bowel syndrome / acute enterocolitis
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6
Q

atropine / hyoscyamine / scopolamine / phenobarbital dosing

A
  • 1-2 tid to qid; MAX of 8 tablets / day

- Extentabs: 1 q12h or 1 q8h

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7
Q

diphenoxylate / atropine brand name and uses

A
  • Lomotil

- diarrhea

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8
Q

diphenoxylate / atropine dosing

A
  • 2.5mg tablets
  • 2 tabs or tsp qid initially, then daily-bid
  • short-term use; DC if no response in 48 hours
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9
Q

loperamide brand name and uses

A
  • Imodium

- diarrhea

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10
Q

loperamide dosing

A
  • Initial 4 mg, then 2 mg after each loose stool (max= 16 mg/day)
  • for chronic diarrhea, slowly titrate maintenance doses downward to lowest effective dose.
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11
Q

lubiprostone brand name and uses

A
  • Amitiza

- irritable bowel syndrome with constipation

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12
Q

lubiprostone dosing

A
  • 8 mcg bid with food and water

- 24 mcg bid for chronic idiopathic and opioid-induced constipation

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13
Q

linaclotide brand name and uses

A
  • Linzess

- irritable bowel syndrome with constipation

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14
Q

linaclotide dosing

A
  • 290 mcg daily on empty stomach 30 minutes prior to 1st meal
  • 145 mcg once daily for chronic idiopathic constipation
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15
Q

polyethylene glycol (PEG) 3350 brand name and uses

A
  • Miralax

- relief of constipation

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16
Q

polyethylene glycol (PEG) 3350 dosing

A
  • 1 scoop (17 g, heaping tbsp) in 8 oz liquid once daily

- use water,juice,soda,tea,coffee; may take 48 - 96 hours for effect

17
Q

PEG / electrolyte solution brand name and uses

A
  • CoLyte

- bowel cleansing prior to GI procedure

18
Q

PEG / electrolyte solution dosing

A
  • 8 oz of reconstituted solution every 10 minutes as directed
  • drink until bowel effluent clear or 4 L gone; chill to improve taste
19
Q

senna brand name and uses

A
  • Ex-Lax

- relief of constipation

20
Q

senna dosing

A
  • 8.6, 15, 17.2, and 25 mg tabs
  • 17.2 mg once daily to 50 mg bid
  • Also available as liquid and syrup
21
Q

docusate sodium and calcium brand name and uses

A
  • Docusate

- relief of constipation

22
Q

docusate sodium and calcium dosing

A
  • Sodium: 50-100 mg bid (or 250 mg daily)
  • Calcium: 240 mg daily
  • take with full glass of water; make take 24 - 72 hours for effect
23
Q

lactulose brand name and uses

A
  • Chronulac
  • constipation
  • portal system encephalopathy (PSE)
24
Q

lactulose dosing

A
  • constipation: 10 - 20 g (15 - 30 mL) daily
  • portal system encephalopathy (PSE): 20 - 30 g (30 - 45 mL) tid - qid
  • make take 24 - 48 hours to produce bowel movement
25
Q

prochlorperazine brand name and uses

A
  • Compazine

- severe nausea / vomiting

26
Q

prochlorperazine dosing

A
  • 5,10 mg tabs, 25mg supp
  • 5 - 10 mg tablet tid - qid
  • 25 mg suppository bid (adult)
27
Q

granisetron brand name and uses

A
  • Kytril

- chemotherapy-induced nausea / vomiting

28
Q

granisetron dosing

A
  • 1 mg tabs
  • 1 mg bid or 2 mg once daily up to 1 hour before chemo
  • pre-medicate with 1st dose up to 60 min before chemo
29
Q

ondansetron brand name and uses

A
  • Zofran
  • chemotherapy-induced nausea / vomiting
  • post-operative nausea / vomiting prophylaxis
30
Q

ondansetron dosing

A
  • 4, 8, 24 mg tabs
  • chemotherapy-induced nausea / vomiting: 8 mg bid; pre-medicate with 1st dose up to 30 min before chemo
  • post-operative nausea / vomiting prophylaxis: 16 mg pre-anesthesia
31
Q

metoclopramide brand name and uses

A
  • Reglan
  • diabetic gastroparesis
  • symptomatic GERD with motility disorder
32
Q

metoclopramide dosing

A
  • diabetic gastroparesis: 5-10 mg qid (30 minutes ac and qhs); 2-8 wk trial of therapy; black box against > 12 wk use
  • symptomatic GERD with motility disorder: 5-15 mg up to qid (30 minutes ac and qhs); black box warning against > 12 wk use
33
Q

trimethobenzamide brand name and uses

A
  • Tigan

- severe nausea / vomiting

34
Q

trimethobenzamide dosing

A

300 mg po tid - qid

35
Q

chlorhexidine gluconate brand name and uses

A
  • Peridex

- oral hygiene rinse

36
Q

chlorhexidine gluconate dosing

A
  • usually 1/2 oz for 30 seconds bid after brushing teeth

- spit; do not swallow; avoid rinses, food or water immediately after

OU Practice Fall 2018 (17 decks)

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