Drugs 1:23-44

Question 1

dipyridamole / aspirin brand name and uses

Answer 1

• Aggrenox

- CVA prevention with h/o TIA or CVA

Question 2

dipyridamole / aspirin dosing

Answer 2

200/25 mg capsule bid

Question 3

pentoxifylline brand name and uses

Answer 3

• Trental

- intermittent claudication

Question 4

pentoxifylline dosing

Answer 4

• 400 mg tid

- 8 week trial to assess effectiveness

Question 5

cilostazol brand name and uses

Answer 5

• Pletal

- intermittent claudication

Question 6

cilostazol dosing

Answer 6

• 100 mg bid (unless interactions)

- max 50 mg bid (interactions); 2-12 week trial

Question 7

warfarin brand name and uses

Answer 7

• Coumadin
• Afib
• venous thromboembolism
• not all inclusive list

Question 8

warfarin dosing

Answer 8

• 2 - 10 mg daily, but highly variable

- average regimen 4 - 5 mg daily

Question 9

dabigatran brand name and uses

Answer 9

• Pradaxa
• DVT/PE prevention / treatment after 5-10 days of parenteral anticoagulant
• stroke prevention in non-valvular Afib

Question 10

dabigatran dosing

Answer 10

• 150 mg twice daily

- for stroke prevention in non-valvular Afib -> 75 mg bid for CrCl 15-30 ml/min

Question 11

rivaroxaban brand name and uses

Answer 11

• Xarelto
• DVT
• PE prevention s/p joint replacement
• DVT/PE treatment
• stroke prevention in non-valvular Afib

Question 12

rivaroxaban dosing

Answer 12

• DVT, PE prevention s/p joint replacement: 10 mg daily; avoid use for indication when CrCl < 30 ml/min
• DVT/PE treatment: 15 mg bid x 21 days, then 20 mg/day with food
• stroke prevention in non-valvular Afib: 20 mg daily with evening meal; 15 mg if CrCl 15-50 ml/min; avoid < 15 ml/min

Question 13

apixaban brand name and uses

Answer 13

• Eliquis
• DVT
• PE prevention s/p joint replacement
• DVT/PE treatment
• stroke prevention in non-valvular Afib

Question 14

apixaban dosing

Answer 14

• DVT, PE prevention s/p joint replacement: 2.5 mg bid (begin 12-24h post-op); therapy duration: hip -35 days, knee-12 days
• DVT/PE treatment: 10 mg bid x 7 days, then 5 mg bid; 2.5 mg bid after 6 months, to decrease risk
• stroke prevention in non-valvular Afib: 5 mg bid

Question 15

edoxaban brand name and uses

Answer 15

• Savaysa
• DVT / PE treatment after 5-10 days of parenteral anticoagulant
• stroke prevention in Afib

Question 16

edoxaban dosing

Answer 16

• DVT, PE treatment: 60 mg daily (30 mg if < 60 kg);

- stroke prevention in Afib: 60 mg daily; 30 mg if CrCl 15-50; avoid if > 95 ml/min

Question 17

furosemide brand name and uses

Answer 17

• Lasix

- CHF

Question 18

furosemide dosing

Answer 18

• 20 - 160 mg split into 1-2x/day

- max oral dose = 600 mg

Question 19

bumetanide brand name and uses

Answer 19

• Bumex

- CHF

Question 20

bumetanide dosing

Answer 20

• 0.5 - 10 mg split into 1-2x/day

Question 21

torsemide brand name and uses

Answer 21

• Demadex
• CHF
• HTN

Question 22

torsemide dosing

Answer 22

• CHF: 10 - 200 mg daily

- HTN: 5 - 10 mg daily

Question 23

hydrochlorothiazide uses

Answer 23

HTN

Question 24

hydrochlorothiazide dosing

Answer 24

• 12.5 - 50 mg daily

- target regimen = 25-50 mg qam

Question 25

indapamide brand name and uses

Answer 25

- Lozol - CHF - HTN

Question 26

indapamide dosing

Answer 26

- CHF: 2.5 - 5 mg daily | - HTN: 1.25 - 2.5 mg daily; target regimen 1.25-2.5 mg qam

Question 27

chlorthalidone uses

Answer 27

HTN

Question 28

chlorthalidone dosing

Answer 28

12.5 - 25 mg daily; target regimen = 12.5-25 mg qam

Question 29

metolazone brand name and uses

Answer 29

- Zaroxolyn | - edema due to CHF/renal dysfunction

Question 30

metolazone dosing

Answer 30

- 2.5 - 20 mg daily | - often used as a 2nd diuretic and/or dosed qod

Question 31

potassium chloride uses

Answer 31

treatment and/or prevention of hypokalemia

Question 32

potassium chloride dosing

Answer 32

16 - 80 mEq split into 1-2x/day

Question 33

spironolactone brand name and uses

Answer 33

- Aldactone - edema (CHF, cirrhosis) - HTN

Question 34

spironolactone dosing

Answer 34

- edema (CHF, cirrhosis): 25 - 200 mg daily | - HTN: 50 - 100 mg daily

Question 35

eplerenone brand name and uses

Answer 35

- Inspra - CHF post MI - HTN

Question 36

eplerenone dosing

Answer 36

- CHF post MI: 25 - 50 mg daily; start 25 mg daily; titrate to 50 mg within 4 weeks - HTN: 50 mg daily; titrate to 50 mg bid after 4 weeks prn

Question 37

ivabradine brand name and uses

Answer 37

- Corlanor | - specific patients with CHF and EF < 35% to decrease hospitalizations due to CHF

Question 38

ivabradine dosing

Answer 38

2.5-5 mg bid initial; 7.5 mg max

Question 39

triamterene 37.5 mg/HCTZ 25 mg brand name and uses

Answer 39

- Dyazide | - HTN

Question 40

triamterene 37.5 mg/HCTZ 25 dosing

Answer 40

1-2 caps daily; use the lowest effective dose

Question 41

triamterene 75 mg/HCTZ 50 mg brand name and uses

Answer 41

- Maxzide | - HTN

Question 42

triamterene 75 mg/HCTZ 50 dosing

Answer 42

1 tab daily

Question 43

sacubitril / valsartan brand name and uses

Answer 43

- Entresto | - CHF

Question 44

sacubitril / valsartan dosing

Answer 44

- (sacubitril/valsartan) 24/26, 49/51, 97/103 | - twice daily (3 strengths)