Drugs 4:14-26

Question 1

diclofenac / misoprostol brand name and uses

Answer 1

• Arthrotec

- arthritic conditions (+ risk of ulcer)

Question 2

diclofenac/misoprostol dosing

Answer 2

• up to 200 mg/800 mcg/day split into 2-4x/day (prefer tid)

- 50 mg/200 mcg, 75 mg/200 mcg; dose bid if GI upset

Question 3

colchicine brand name and uses

Answer 3

• Colcrys
• gout prophylaxis
• gout treatment (acute flare)

Question 4

colchicine dosing

Answer 4

• 0.6 mg tablets
• gout prophylaxis: 0.6 mg once or twice daily (max: 1.2 mg/day)
• gout treatment (acute flare): Day 1: 1.2 mg, then 0.6 mg in 1 hour or 0.6 mg TID (max: 1.8 mg/day), Day 2 and maintenance: 0.6 mg once or twice daily until flare resolves

Question 5

allopurinol brand name and uses

Answer 5

• Zyloprim

- gout treatment

Question 6

allopurinol dosing

Answer 6

• 100-800 mg daily split into 1-3x/day

- Doses > 300 mg may be given in divided doses; 100 and 300 mg tablets; 500 mg intravenous

Question 7

methotrexate uses

Answer 7

rheumatoid arthritis

Question 8

methotrexate dosing

Answer 8

• wkly: 7.5 mg x 1 day or 2.5 mg q 12h x 3 doses

- 2.5 mg tab, 25 mg/ml injection; max dose 20 mg/wk

Question 9

cyclosporine brand name and uses

Answer 9

• Sandimmune

- rheumatoid arthritis

Question 10

cyclosporine dosing

Answer 10

• 2.5 mg/kg/day (max: 4 mg/kg/day) split into bid
• 25 mg, 100 mg tabs
• Titrate by 0.5 to 0.75 mg/kg/day if insufficient response after 8 weeks.
• DC if no response by 16 wks.

Question 11

azathioprine brand name and uses

Answer 11

• Imuran

- rheumatoid arthritis

Question 12

azathioprine dosing

Answer 12

• 1 mg/kg/day split into 1-2x/day
• 50 mg tabs
• After 6 to 8 wks, titrate by 0.5 mg/kg every 4 wks until 4.19 Imuran azathioprine rheumatoid arthritis 1 mg/kg/day 1 to 2
  response or up to 2.5 mg/kg/day; adequate trial is minimum of 12 wks.

Question 13

cyclobenzaprine brand name and uses

Answer 13

• Flexeril

- musculoskeletal conditions

Question 14

cyclobenzaprine dosing

Answer 14

• 15 - 30 mg/day split into tid

- 5, 10 mg tablets; short-term (3 weeks)

Question 15

methocarbamol brand name and uses

Answer 15

• Robaxin

- musculoskeletal conditions

Question 16

methocarbamol dosing

Answer 16

• 3 - 4 grams/day split into qid

- 500, 750 mg tablets; doses of 6 g/day for the first 2-3 days (up to 8 g)

Question 17

orphenadrine brand name and uses

Answer 17

• Norflex

- musculoskeletal conditions

Question 18

orphenadrine dosing

Answer 18

• 200 mg/day split into bid

- 100 mg SR tablet, 30 mg/ml injection

Question 19

metaxalone brand name and uses

Answer 19

• Skelaxin

- musculoskeletal conditions

Question 20

metaxalone dosing

Answer 20

• up to 3200 mg/day split into 3-4x/day

- 800 mg tablets

Question 21

carisoprodol brand name and uses

Answer 21

• Soma

- musculoskeletal conditions

Question 22

carisoprodol dosing

Answer 22

• up to 1400 mg/day split into qid
• 250, 350 mg tablets
• duration of 2 to 3 wks

Question 23

tizanidine brand name and uses

Answer 23

• Zanaflex

- management of spasticity

Question 24

tizanidine uses

Answer 24

• 6 - 36 mg/day split into tid

- 2, 4, 6 mg capsules, 2 and 4 mg tablet

Question 25

baclofen brand name and uses

Answer 25

• Lioresal

- management of spasticity

Question 26

baclofen uses

Answer 26

• 15 mg - 80 mg/day split into 3-4x/day
• 10, 20 mg tabs, titrate 15 mg q3days
• also intrathecal soln