Drugs 3:1-19

Question 1

glimepiride brand name and uses

Answer 1

• Amaryl

- Type 2 diabetes

Question 2

glimepiride dosing

Answer 2

1 - 8 mg

Question 3

glipizide brand name and uses

Answer 3

• Glucotrol (XL)

- Type 2 diabetes

Question 4

glipizide dosing

Answer 4

• 2.5 - 40 mg split into 1-2x/day; titrate q1-2wks; divide dose > 15 mg as bid
• XL: 2.5 - 20 mg qd; titrate q1-2wks

Question 5

glyburide brand name and uses

Answer 5

• Diabeta / (Micronase)

- Type 2 diabetes

Question 6

glyburide dosing

Answer 6

• 1.25 - 20 mg split into 1-2x/day

- titrate q1-2wks; divide dose > 10 mg as bid

Question 7

repaglinide brand name and uses

Answer 7

• Prandin

- Type 2 diabetes

Question 8

repaglinide dosing

Answer 8

• 0.5 - 4 mg tid

- titrate weekly; take 15 minutes pre-meal (0-30 min); max 16 mg/24hrs

Question 9

nateglinide brand name and uses

Answer 9

• Starlix

- Type 2 diabetes

Question 10

nateglinide dosing

Answer 10

• 60 - 120 mg tid

- titrate weekly; take 15 minutes pre-meal (0-30 min)

Question 11

acarbose brand name and uses

Answer 11

• Precose

- Type 2 diabetes

Question 12

acarbose dosing

Answer 12

• 25 - 100 mg tid

- titrate q4-8wks; skip if meal is missed; max dose by weight

Question 13

pioglitazone brand name and uses

Answer 13

• Actos

- Type 2 diabetes

Question 14

pioglitazone dosing

Answer 14

• 15 - 45 mg

- titrate q3months

Question 15

rosiglitazone brand name and uses

Answer 15

• Avandia

- Type 2 diabetes

Question 16

rosiglitazone dosing

Answer 16

• 4 - 8 mg split into 1-2x/day

- titrate q3months

Question 17

metformin brand name and uses

Answer 17

• Glucophage (XR), Glumetza

- Type 2 diabetes

Question 18

metformin dosing

Answer 18

• 1000 - 2550 mg split into 2-3x/day; start 500 mg qd; titrate 500 mg qwk or 850 mg every other wk; with food
• XR: 500 - 2000 mg qd; with evening meal; can switch to XR at equal dose
• Glumetza: 1000 - 2000 mg with evening meal

Question 19

glipizide/metformin brand name and uses

Answer 19

• Metaglip

- Type 2 diabetes

Question 20

glipizide/metformin dosing

Answer 20

• BID

- titrate q2wks; max 20/2000 mg per 24 hrs

Question 21

glyburide/metformin brand name and uses

Answer 21

• Glucovance

- Type 2 diabetes

Question 22

glyburide/metformin dosing

Answer 22

• BID

- titrate q2wks; max 20/2000 mg per 24 hrs

Question 23

pioglitazone/metformin brand name and uses

Answer 23

• Acto Plus Met

- Type 2 diabetes

Question 24

pioglitazone/metformin dosing

Answer 24

• BID

- max 45/2550 mg per 24 hrs

Question 25

sitagliptin brand name and uses

Answer 25

• Januvia

- Type 2 diabetes

Question 26

sitagliptin dosing

Answer 26

• 100 mg

- dosage adjustment for CrCl < 50 ml/min

Question 27

saxagliptin brand name and uses

Answer 27

• Onglyza

- Type 2 diabetes

Question 28

saxagliptin dosing

Answer 28

• 2.5 - 5 mg

- dosage adjustment for CrCl < 50 ml/min or with strong CYP 3A4 inhibitors

Question 29

linagliptin brand name and uses

Answer 29

• Tradjenta

- Type 2 diabetes

Question 30

linagliptin dosing

Answer 30

• 5 mg

- no dosage adjustment recommended for renal impairment

Question 31

alogliptin brand name and uses

Answer 31

• Nesina

- Type 2 diabetes

Question 32

alogliptin dosing

Answer 32

• 25 mg

- 6.25 mg for CrCl 15 to 29 ml/min , 12.5mg for CrCl 30 to < 60ml/min

Question 33

canagliflozin brand name and uses

Answer 33

• Invokana

- Type 2 diabetes

Question 34

canagliflozin dosing

Answer 34

• 100 - 300 mg

- prior to the first meal; lower dose for CrCl < 60 ml/min, avoid if < 45 ml/min

Question 35

dapagliflozin brand name and uses

Answer 35

• Farxiga

- Type 2 diabetes

Question 36

dapagliflozin dosing

Answer 36

• 5 - 10 mg

- for CrCl > 60 ml/min; not recommended < 60 ml/min, contraindicated < 30

Question 37

empagliflozin brand name and uses

Answer 37

• Jardiance

- Type 2 diabetes

Question 38

empagliflozin dosing

Answer 38

• 10 - 25 mg

- for CrCl > 45 ml/min; not recommended < 45 ml/min, contraindicated < 30