Drug Profiles: Diazapam, Lorazapam, Midazolam

Question 1

midazolam (Versed): precautions

Answer 1

monitor respiratory status

Question 2

lorazepam (Ativan): side effects

Answer 2

Hypotension, respiratory depression

Question 3

diazepam (Valium): side effects

Answer 3

hypotension, respiratory depression

Question 4

diazepam (Valium): class

Answer 4

benzodiazepines, anticonvulsant, sedative, hypnotic

Question 5

Diazapam (Valium): Dosage

Answer 5

5-15 mg IV

Question 6

lorazepam (Ativan): interactions

Answer 6

Effects are additive when used with other CNS depressants, for example, alcohol

Question 7

Lorazepam (Ativan): class

Answer 7

benzodiazepine, anticonvulsant, sedative, hypnotic

Question 8

midazolam (Versed): interactions

Answer 8

Effects are additive when used with other CNS depressants, for example, alcohol.

Question 9

Lorazepam (Ativan): Indications

Answer 9

Major motor seizures, premedication for cardioversion ot TCP, sedation associated with intubation, muscle spasms, acute anxiety, agitation (amphetamine or cocaine OD)

Question 10

LORAZEPAM (ATIVAN): pharmacokinetics

Answer 10

Onset: 1-2 min IV; 15 min IM
Duration: 30-60 min IV, IM

Question 11

diazepam (Valium): mechanism of action

Answer 11

Enhances action of GABA, an inhibitory
neurotransmitter, which inhibits spread of electrical
activity from irritable focus during seizures, calms CNS.
Also a muscle relaxant.

Question 12

midazolam (Versed): side effects

Answer 12

Laryngospasm, bronchospasm, respiratory depression, drowsiness, amnesia, altered mental status

Question 13

diazepam (Valium): precautions

Answer 13

Cannot be given IM. If possible use large vein and give slowly because of possible venous irritation. Monitor respiratory status

Question 14

Diazapam (Valium): Indications

Answer 14

Major motor seizures, premedication for cardioversion ot TCP, sedation associated with intubation, muscle spasms, acute anxiety, agitation (amphetamine or cocaine OD)

Question 15

Lorazepam (Ativan): Dosage

Answer 15

0.05mg/kg IV, max is generally 4mg

Question 16

diazepam (Valium):pharmacokinetics

Answer 16

Onset: 2-4 minutes
Duration: 30-90 minutes

Question 17

midazolam (Versed): mechanism of action

Answer 17

Enhances action of GABA, an inhibitory neurotransmitter; inhibits spread of electrical activity from irritable focus during seizures, calms CNS. Also a muscle relaxant.

Question 18

Midazolam: Dosage

Answer 18

RSI: 0.1mg/kg IV, Max 10mg Other sedation/seizure: 2.5mg-10mg IV/IM

Question 19

Lorazepam (Ativan): Contraindications

Answer 19

Hypotension, head injury and/or decreased mental status unless being given during RSI

Question 20

Midazolam (Versed): Indications

Answer 20

Major motor seizures, premedication for cardioversion ot TCP, sedation associated with intubation, muscle spasms, acute anxiety, agitation (amphetamine or cocaine OD)

Question 21

midazolam (Versed): class

Answer 21

benzodiazepine, anticonvulsant, sedative, hypnotic

Question 22

diazepam (Valium): interactions

Answer 22

Effects are additive when used with other CNS depressants, for example, alcohol

Question 23

midazolam (Versed): pharmacokinetics

Answer 23

Onset: 1-2 min IV; 15 min IM
Duration: 30-60 min IV, IM

Question 24

Midazolam: Contraindications

Answer 24

Hypotension, head injury and/or decreased mental status unless being given during RSI.