Drug delivery systems Flashcards
What 3 factors are important to think about, when figuring out what method of drug delivery to use for a patient?
Dosage
Frequency of administration
Timing of administration
Why might you choose to give a drug as a solution or suspension?
If the patient is very young, very old or has problems swallowing pills etc
If you want the drug to be absorbed heavy rapid
WHat are the benefits of using prolonged or delayed release formulations?
Prolonged therapy
Maintains drug levels withing therapeutic range
Reduces frequency of dosing needed
Easier for patient - less pills to take
Easier for nurses and doctors - less pills to give out
What angle would you give a muscular injection at?
90 degrees to skin
WHat angle would you give a sub-cutaneous injection at?
45 degrees
What angle would you give a intradermal injection at?
10 - 15 degrees
Why would you choose to give a patient IV drugs?
Rapid onset required
Careful control of plasma required
If the drug is easily metabolised (first pass metabolism)
If the drug has a short half life
List the different carrier based drug delivery systems
Micelles Vesicles Multifuntional dendritic polymers Liquid crystals Nanocapsules Nanospheres
Monoclonal antibodies are often used in the treatment of what?
Cancer
Why is nanoparticle based drug delivery beneficial?
Specific targetting so more effective while reducing side effects
Give examples of what nanoparticles are used to treat
Bronchial asthma Cancer (chemotherapy) Liver tumours Parasitic disease Enzyme disease Targeting HIV and adenovirus
What does percutaneous mean?
Creams, ointments, skin patches
Drugs administered to skin
