DNA: Nucleotides Flashcards
Are responsible for the storage and passage of the information needed for the production of proteins
Nucleic acids
Are the monomeric units that make up the nucleic acids DNA and RNA
Nucleotides
Each nucleotide contains of a
Pentose sugar, Nitrogenous base & Phosphate group “PNP”
Result from linking one or more phosphates with a nucleoside onto the 5’ end of the molecule through _________.
Nucleotides. Esterification
Is a 5 carbon sugar in a pentose ring form
Pentose sugar
RNA contains ________, which has a hydroxyl group in both the 2’ and 3’ positions.
Ribose
Refers to the carbon of the sugar
Prime
Has only a single hydroxyl group in the 3’ position
DNA
A nitrogenous base is attached by a __________ to the 1’ carbon of the nucleotide’s sugar.
Glycosylic bond
Consist of linked 5-membered and 6-membered rings w/c can be found in DNA or RNA. _______ and _______.
Purines. Adenine & Guanine and A & G.
Consists of 6-membered rings. ________, _______ & _______.
Pyrimidines. Cytosine, Thymine and Uracil “CTU”
Cytosine is found in
DNA & RNA
Thymine is found where
DNA
Uracil is found where
RNA
Are planar, aromatic and heterolytic. Derived from _______ & ______. Numbering of bases is unprimed.
Nitrogenous bases. Purine & Pyrimidine.
In nitrogenous base, the sugar is linked via ______ to the ___ of pyrimidines and ___ of purines.
B-N-glycosylic bond. N-1. N-9.
De novo synthesis proceeds via
Triphosphate intermediates
Purine nucleosides end in
Sine
Pyrimidine nucleosides end in
Dine
Nucleotides are linked together by ________ between the __ hydroxyl on the sugar of one nucleotide through a ________ to the __ hydroxyl on the sugar of another nucleotide. These bonds are broken by _________.
Phosphodiester bonds. 3’. Phosphate molecule. 5’. Phosphodiesterases.
High group transfer potential of __________ permits them to function as group transfer agent (give x)
Nucleoside Triphosphates
For synthesis of cyclic AMP and cyclic GMP ( a second messenger in response to nitric oxide during smooth muscle relaxation) and fro methyl group transfer (SAM)
Nucleotides
Participate in the epimerization of sugars for glycogen synthesis, bilirubin synthesis, and phosphoglyceride synthesis.
UPD sugars
Absorb UV lights
Nucleotides
are used as antivirals and in cancer chemotherapy
Synthetic nucleotide analogues