Diuretics questions Flashcards
if no hypokalemia, what is drug? (more than one)
Amiloride, Triamterene, Spironolactone?
What drugs are used when pt has bipolar disorder/lithium use? (2)
Amiloride, triamterene
between amiloride and triamterene, which is nephrotoxic?
triamterene
which K+ sparing diuretic can be used in CHF
Spironolactone
which K+ sparing diuretic is preferred in cirrhosis
Spironolactone
What is the only class that causes K= wasting with mtb acidosis!
CA inhibitors
Which drug class causes hypercalcemia? hypocalcemia
hyper = thiazides hypo = loop
Which class requires good GFR and which does not?
Needs good GFR = Thiazides
Does not need good GFR = Loop
Which Diuretics Can Exacerbate Gout
Loop, Thiazides
Which diuretic blocks the effect of aldosterone on the heart
spironolactone
Which 2 actions of Diuretics Cause Kidney Stones?
Those that increase pH of urine
Those that increase calcium excretion
Which diuretics increase calcium excretion
loops
Which diuretics ncrease pH of urine
CA inhibitors
Which diuretics treat Kidney stones and MOA
MOA: increase reab of clacium
Thiazides
Which cause ototoxicity and MOA
Loops
MOA: inhibit NKCC transporter
Which diuretic is used for a patient with pulmonary edema and/ or
decreased renal function?
Loops
Sam is a 67 year old man who has had poorly controlled hypertension for the past 15 years, and now presents with signs of ankle edema, a low GFR and a serum creatinine of 2.5 mg/dL. The most effective drug for producing a diuresis and fall in blood pressure in DM is:
furosemide
Which drug reduces mortality by ~30% in patients with heart failure and liver dysfunction that develops after a myocardial infarction?
spironolactone
What side effects do you warn them about spironolactone (3)?
Impotence
Reduced libido
gynecomastia
Gertrude is a 65 year old woman that has been diagnosed with hypercalcemia related to a parathyroid hormone secreting tumor. In addition to her chemotherapy what other drug do you put her on? What side effect do you warn her about?
furosemide
ototoxicity
What diuretic drug acts on the proximal tubule, is not that good at blocking Na+ reabsorption, but is useful for treatment of glaucoma and acute mountain sickness?
acetazolamide
Which drug class prodices rise in LDL and decreases glucose tolerance
Thiazides
Which is the most useful agent for the treatment of recurrent calcium stones?
thiazide
Which class ADEs: Elevated plasma uric acid and triglycerides
thiazides
Which diuretic would you use in a patient with cerebral edema??
mannnitol
Cix fro mannitol
active bleeding
A 70 year old woman complains of paresthesias and occasional nausea associated with one of her drugs. She is found to have hyperchloremic metabolic acidosis. She is probably taking
acetazolamide
which drug classes cause hyperuricemia (2)
loops, thiazides
