Diuretics questions

Question 1

if no hypokalemia, what is drug? (more than one)

Answer 1

Amiloride, Triamterene, Spironolactone?

Question 2

What drugs are used when pt has bipolar disorder/lithium use? (2)

Answer 2

Amiloride, triamterene

Question 3

between amiloride and triamterene, which is nephrotoxic?

Answer 3

triamterene

Question 4

which K+ sparing diuretic can be used in CHF

Answer 4

Spironolactone

Question 5

which K+ sparing diuretic is preferred in cirrhosis

Answer 5

Spironolactone

Question 6

What is the only class that causes K= wasting with mtb acidosis!

Answer 6

CA inhibitors

Question 7

Which drug class causes hypercalcemia? hypocalcemia

Answer 7

hyper = thiazides
hypo = loop

Question 8

Which class requires good GFR and which does not?

Answer 8

Needs good GFR = Thiazides

Does not need good GFR = Loop

Question 9

Which Diuretics Can Exacerbate Gout

Answer 9

Loop, Thiazides

Question 10

Which diuretic blocks the effect of aldosterone on the heart

Answer 10

spironolactone

Question 11

Which 2 actions of Diuretics Cause Kidney Stones?

Answer 11

Those that increase pH of urine

Those that increase calcium excretion

Question 12

Which diuretics increase calcium excretion

Answer 12

loops

Question 13

Which diuretics ncrease pH of urine

Answer 13

CA inhibitors

Question 14

Which diuretics treat Kidney stones and MOA

Answer 14

MOA: increase reab of clacium

Thiazides

Question 15

Which cause ototoxicity and MOA

Answer 15

Loops

MOA: inhibit NKCC transporter

Question 16

Which diuretic is used for a patient with pulmonary edema and/ or
decreased renal function?

Answer 16

Loops

Question 17

Sam is a 67 year old man who has had poorly controlled hypertension for the past 15 years, and now presents with signs of ankle edema, a low GFR and a serum creatinine of 2.5 mg/dL. The most effective drug for producing a diuresis and fall in blood pressure in DM is:

Answer 17

furosemide

Question 18

Which drug reduces mortality by ~30% in patients with heart failure and liver dysfunction that develops after a myocardial infarction?

Answer 18

spironolactone

Question 19

What side effects do you warn them about spironolactone (3)?

Answer 19

Impotence
Reduced libido
gynecomastia

Question 20

Gertrude is a 65 year old woman that has been diagnosed with hypercalcemia related to a parathyroid hormone secreting tumor. In addition to her chemotherapy what other drug do you put her on? What side effect do you warn her about?

Answer 20

furosemide

ototoxicity

Question 21

What diuretic drug acts on the proximal tubule, is not that good at blocking Na+ reabsorption, but is useful for treatment of glaucoma and acute mountain sickness?

Answer 21

acetazolamide

Question 22

Which drug class prodices rise in LDL and decreases glucose tolerance

Answer 22

Thiazides

Question 23

Which is the most useful agent for the treatment of recurrent calcium stones?

Answer 23

thiazide

Question 24

Which class ADEs: Elevated plasma uric acid and triglycerides

Answer 24

thiazides

Question 25

Which diuretic would you use in a patient with cerebral edema??

Answer 25

mannnitol

Question 26

Cix fro mannitol

Answer 26

active bleeding

Question 27

A 70 year old woman complains of paresthesias and occasional nausea associated with one of her drugs. She is found to have hyperchloremic metabolic acidosis. She is probably taking

Answer 27

acetazolamide

Question 28

which drug classes cause hyperuricemia (2)

Answer 28

loops, thiazides