Class: Breast Neoplasias Flashcards

1
Q

MC type of breast cancer

A

Infiltrating ductal cancer is the MC by far

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2
Q

what is the most important prognostic factor in cancer?

A

Nodal or extranodal is

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3
Q
A 52yo lady presents for routine examination, you obtain a screening mammography which shows a cluster of small calcifications in the left breast. Your send her for a stereotactic-guided core biopsy and get these tissue results. What is the most likely diagnosis?
Ductal carcinoma in situ
Invasive ductal carcinoma
Usual Ductal Hyperplasia
Atypical ductal hyperplasia
A

Atypical ductal hyperplasia

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4
Q

what cancer shows necrotic calciications in ducts

A

Ductal carcinoma in situ DCIS (comedo type)

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5
Q

How to tell the difference betwen Ductal Carinoma in Situ (DCIS) and Atypical Ductal hyperplasia

A

Neoplastic cells do not completely fill the duct space in ADH

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6
Q

E-cadherin negative stain means what dx? calcifications present?

A

LCIS (lobular carcinoma in situ)

no calcifications

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7
Q

Desmoplastic stroma- is part of what cancer

A

Infiltrating Ductal Carcinoma

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8
Q

describe the tumor of a Infiltrating Ductal Carcinoma

A

Hard, chalky white, gritty, (“crab-like”)

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9
Q

which cancer has cells that lavk E-cadherin

A

invading lobular carcinoma (also lobular carcinoma in-situ)

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10
Q

Which underlying carcinoma is pagets disease of the nipple assc with

A

DCIS

ductal carcinoma in situ

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11
Q

What does inflammatory disease of the nipple present with

A

peau d’ orange gross morphology

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12
Q

2 risk factors for male BC

A

BRCA 2, Klinefleters

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13
Q

ER/PR+ respond to what drug

A

tamoxifen

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14
Q

What action does tamoxifen have at breast, uterus, bone

A

antagonizes Estrogen/progesterone at breast

aginist at bone, uterus

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15
Q

Her2+ leads to treatment with what?

A

Herceptin

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16
Q

Mobile lump is what dx in :
young
old

A

young: fibroadenoma

old = phylloides

17
Q

cyclical pain leads to what dx

A

fibrocystic change

18
Q

Clear pus from nipple–> what dx

A

duct ectasia

19
Q

bloody discharge –> dx? (2)

A

duct papilloma, DCIS

20
Q

nipple eczema–> what dx?

A

pagets disease of breast

21
Q

MC mass in:
young women
women >50 (generally)

A

young wmoen = fibrocystic breast disease

> 50 = breast cancer

22
Q

Single most prognostic factor in breast cancer is?

A

lymph node or extranodal involvement

23
Q

DCIS shows what on mammo

A

microcalcifications on mammo

24
Q

DCIS show s what HISTO?

A

filling the ducts on histo (comedocarcinoma)

25
Q

3 cancers with poor px

A

triple negatove
inflammatory
male

26
Q

Consider BRCA testing for patients with breast cancer in these pops (3)

A

< 50y triple negative tumor
invasive ovarian/fallopian tube, peritoneal cancer
more than 2 family members with history of breast cancer

27
Q

why no mammo in younger pts

A

High false-positive mammogram in younger patients

28
Q

What is Breast cancer screening 40-50y?

A

talk to your patient to determine plan