Class: Breast Neoplasias Flashcards
MC type of breast cancer
Infiltrating ductal cancer is the MC by far
what is the most important prognostic factor in cancer?
Nodal or extranodal is
A 52yo lady presents for routine examination, you obtain a screening mammography which shows a cluster of small calcifications in the left breast. Your send her for a stereotactic-guided core biopsy and get these tissue results. What is the most likely diagnosis? Ductal carcinoma in situ Invasive ductal carcinoma Usual Ductal Hyperplasia Atypical ductal hyperplasia
Atypical ductal hyperplasia
what cancer shows necrotic calciications in ducts
Ductal carcinoma in situ DCIS (comedo type)
How to tell the difference betwen Ductal Carinoma in Situ (DCIS) and Atypical Ductal hyperplasia
Neoplastic cells do not completely fill the duct space in ADH
E-cadherin negative stain means what dx? calcifications present?
LCIS (lobular carcinoma in situ)
no calcifications
Desmoplastic stroma- is part of what cancer
Infiltrating Ductal Carcinoma
describe the tumor of a Infiltrating Ductal Carcinoma
Hard, chalky white, gritty, (“crab-like”)
which cancer has cells that lavk E-cadherin
invading lobular carcinoma (also lobular carcinoma in-situ)
Which underlying carcinoma is pagets disease of the nipple assc with
DCIS
ductal carcinoma in situ
What does inflammatory disease of the nipple present with
peau d’ orange gross morphology
2 risk factors for male BC
BRCA 2, Klinefleters
ER/PR+ respond to what drug
tamoxifen
What action does tamoxifen have at breast, uterus, bone
antagonizes Estrogen/progesterone at breast
aginist at bone, uterus
Her2+ leads to treatment with what?
Herceptin