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D&T test 5 - Renal, Urogential > Class: Papilloma, Polyoma, Parvo > Flashcards

Class: Papilloma, Polyoma, Parvo Flashcards

1
Q

What kinds of cancer are caused by HPV (6)

A

99% cervical cancers
Anal cancers
vuvlar, vaginal, penile
oropharyngeal cancers

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2
Q

What are the high risk HPV types most assocuated with cancers

A

16, 18

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3
Q

What does a low risk E6 viral protein do vs high risk

A 
low = does not inactivate p53
high = inactivates p53
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4
Q

What does a high risk E7 viral protein do vs low risk?

A 
low = weakly binds and does not degrade Rb
high = binds and degrades Rb
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5
Q

What is the AIDs defining cancer in HIV+ woman

A

cervical

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6
Q

The incidence of what cancers are higher in the HIV+ population

A

anal and oropharyngeal

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7
Q

What HPV type causes common warts (verrucus vulgaris)

A

types 1,2,4

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8
Q

What HPV type causes Plane warts or flat warts (verrucae plana)

A

types 3, 10

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9
Q

What HPV type causes Plantar warts (verrucae plantaris)-

A

types 1, 2

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10
Q

what is epidermodysplasia verruciform? Inheritance pattern?

A

AR - chronic infection of cutaneous HPV

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11
Q

What HPV types are assc with epidermodysplasia verruciform

A

types 3, 10

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12
Q

what is recurrent respiratory papillomatosis ?

A

warts that appear in larynx and spread to lung

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13
Q

How does recurrent respiratory papillomatosis present? (3)

A

warts in resp tract
hoarseness is first sx
difficulty swallowing or breathing while sleeping

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14
Q

What HPV types causerecurrent respiratory papillomatosis

A

types 6, 11

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15
Q

how is recurrent respiratory papillomatosis transmitted in Juvenile and adult

A 
juvenile = birth
adult = oral sex
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16
Q

3 treatments of recurrent respiratory papillomatosis

A

frequent surgeries
IFN or cidofovir to reduce time between surgeries
Indole-3 carbinol

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17
Q

in Cervarix vaccine what HPV virus types are present?

A

Bivalent-16,18 only

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18
Q

Gardasil: quadrivalent, vaccine what virus types are present?

A

HPV 6, 11, 16, 18

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19
Q

Gardasil 9: 9-valent, what types are repsent?

A

HPV 6, 11, 16, 18 and 10% of other high risk HPV’s

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20
Q

What is the optimal age of HPV vaccination?

A

11-12

21
Q

How many shots do the following age groups get?
9
11-14
15- 21 (boys), -26 (girls)

A

9 = 2 doses

11-14 = 2 doses

15-21 get 3 doses

22
Q

cervarix only approved for who

A

girls

23
Q

Gardasil bi- and quadrivalent approved for what pop?

A

boys and girls

24
Q

who is at risk for PML? (3)

A
  1. AIDs pts
  2. Immunosuppressed -dt transplant, hematologic malignancies
  3. Those on immunosuppressive thx: Crohn’s, MS, rheumatoid arthritis, psoriasis, SLE
25
Q

What virus (and family) causes PML?

A

JC virus (polyoma family)

26
Q

Why such a small incidence of PML even in the immune suppressed?

A

Several steps are needed to get to PML from a JC infection:

27
Q

What are the 3 steps needed to cause PML

A
  1. virus needs to change to infect glial cells
  2. needs to get to brain
  3. needs to evade immune surveillance in brain
28
Q

What cells does PML infect?

A

infects oligodendrocytes and astrocytes

29
Q

How does PML cuase it’s sx?

A

causes a multifocal demyelination of the white mater

30
Q

What does IRIS stand for

A

(Immune Reconstitution Inflammatory Syndrome)

31
Q

What is IRIS associated with and what increases risk?

A

associated with use of immunosuppressant Natalizumab

increased risk with increased time on drug

32
Q

tx for IRIS

A

corticosteroid

33
Q

What 2 problems does BK virus cause in kidney transplant pts

A

some develop BK-associated nephropathy

of those 50% reject the trasnplant

34
Q

What problems arise in Bk- infected allogenic hematopoietic stem cell transplant pts

A

increased risk for hemorrhagic cystitis

35
Q

What cell is found in urine of BK pt

A

decoy cells

36
Q

what virus causes erythema infectiosum

A

Parvovirus B-19

37
Q

How is parvovirus B-19 transmitted. (2)

A

respiratory droplets

TORCHES = congential

38
Q

What is parvovirus B-19 receptor?

A

globoside (also known as blood group P antigen).

39
Q

How is erythema infectiosum transmitted.

A

resp droplets and fomites

40
Q

wHAT CELL TYPE IS TARGET FOR parvovirus? why?

A

erythroid precursor cells

In order to replicate needs to infect cells that are actively dividing

41
Q

How does erythema infectiosum presetn in children

A

fever–> slapped cheek rash –> recovery

42
Q

How does erythema infectiosum presetn in adults

A

arthritis/arthralgia in small joints in hands, and feet (also knee)

43
Q

What can erythema infectiosum be mistaken for in adults?

A

Rheumatoid arthritis

44
Q

Two main complications of erythema infectiosum

A

Transient aplastic crisis (TAC)

Pure Red Cell Aplasia

45
Q

In what pop does Pure Red Cell Aplasia occur

A

immunosuppressed

46
Q

In what pop does Transient aplastic crisis (TAC) occur

A

people with hemoglobinopathies: MC = SSD, but also

thalassemia, hereditary spherocytosis, red cell enzymopathies, and autoimmune hemolytic anemia.

47
Q

what the outcome can be for pregnant women infected with B19.

A

high output cardiac failure and non-immune hydrops fetalis.

48
Q

When during gestation does parvo B-19 infx becomes most problematic

A

Highest risk is in first 20 weeks of pregnancy

49
Q

What is major complication of fetal B-19 infx and MOA

A

B19 infects fetal myocytes expressing the P-antigen –> myocarditis–> hydrops fetalis

D&T test 5 - Renal, Urogential (27 decks)

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