Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

D&T test 5 - Renal, Urogential > Class: Herpes : HSV1, 2, VZV > Flashcards

Class: Herpes : HSV1, 2, VZV Flashcards

1
Q

WHat type of herpes virus are HSV and VZV

A

alpha

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which herpesvirus causes neonatal herpes

A

HSV 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Which herpesvirus causes oral herpes

A

HSV 1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which herpesvirus causes encephalitis

A

HSV-1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What antivirals to use if viral resistance develops (2) (MOA)

A

Cidofovir and Foscarnet - Don’t need to be activated by viral kinases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

ADEs of Acyclovir: (1)

A

IV - can crystalize in the kidney - need to infuse slowly and hydrate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

ADEs of gangciclovir (2)

A

neutropenia, thrombocytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Cidofovir ADEs (2)

A

renal toxicity

neutropenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Foscarnet ADEs (2)

A

renal toxicity

neutropenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Where do HSV 1 and 2 infect

A

mucosal epithelial cells,

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What site is especially rare for HSV-2 infx but common for HSV-1

A

oral mucosa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

MC form of transmission of genital HSV-1

A

oral sex (that’s right)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How is HSV-2 MC spread

A

Most commonly get HSV-2 from asymptomatically shedding partner.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Where are HSV-1 and 2 latent (2)

A

oral - trigeminal ganglia

genital - sacral ganglia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

VSV is latent in what 3 places

A

dorsal root, cranial nerve, trigeminal nerve

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What drugs used to treat primary outbreaks of HSV

A

All cyclovirs work.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

3 complications fo HSV 1 and 2 infx

A

Meningitis with HSV-2 but not HSV-1
cervicitis-70-90%
Herpes proctitis (rectal lesions)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Which complication is seen in HSV-2 but NOT in HSV-1

A

meningitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is diffrence between primary and recurrent outbreaks of HSV 1 and 2?

A

Not as long and without systemic symptoms of primary outbreak - so no fever malaise

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Which virus (1 or 2 ) asx sheds more often

A

HSV 2&raquo_space;>HSV 1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

How often does HSV 2 shedding occur?

A

every 10 days for 2-12 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What 3 antivirals are used to reduce shedding, transmission and recurrences? how often dosed?

A

acyclovir, valacyclovir, or famciclovir

Daily

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

When do you have to take oral acyclovir, valacyclovir or famciclovir to reduce symptoms of recurrence

A

prodromal stage.

24
Q

Which HSV is spread through sex

A

both

25
Q

over half of genital herpes is what type

A

HSV 1

26
Q

both viruses express what in latency?

A

LAT (Latency Associated Transcripts)

27
Q

The risk of acquiring HIV infection is higher if you have what location of what type of HSV infx

A

genital HSV-2

28
Q

which HSV is MC cause of herpetic whitlow

A

HSV-1

29
Q

which HSV is MC cause of herpetic gladitorum

A

HSV -1

30
Q

which HSV is MC cause of ocular herpes

A

HSV-1

31
Q

The number 1 cause of infectious blindness in developed countries

A

Herpes Keratitis

32
Q

Sx of herpes keratitis

A

Staining of the eye shows dendritic lesion, areas of ulceration

33
Q

tx to avoid in herpes keratits

A

steroids

34
Q

Which eye infx of herepes is less common in primary infx but MC in recurrences?

A

Stromal Keratitis

35
Q

What is tx for ocular herpes (2)

A

antiviral eye drops, and/or oral acyclovir

36
Q

Which HSV is MC cause of temporal/frontal lobe encephalitis

A

HSV-1

37
Q

What are 2 ways to dx HSV encephalitis?

A

PCR of CSF (may be negative in early infx)

MRI

38
Q

tx for temporal/frontal lobe encephalitis

A

IV acyclovir as early as possible

39
Q

Which herpes virus is a TORCH vinfx

A

HSV-2

40
Q

What is risk of transmission to baby if primary infx occurs < 12 weeks before birth

A

40%

41
Q

What is risk of transmission to baby if primary infx occurs MORE THAN 12 weeks before birth or with RECURRENT infx

A

1-2%

42
Q

What is tx for pregnant woman having any Herpes lesions in pregnancy. (drug and # of weeks given and the procedure) - so 2 things

A

Acyclovir suggested at 36 weeks

C-sections reduce but do not abolish risk

43
Q

Dx of neonatal Herpes (3 tests you must do all three)

A

1) Surface cultures
2) If vesicles are present: scrapings/swabs with culture
3) PCR of CSF

44
Q

What are the main means of spread of varicella (2)

A

respiratory droplets, lesions

45
Q

Complications Varicella infection (4)

A

secondary bacterial infx of skin
Reyes syndrome - with ASA use
CNS manifestations
PNA-

46
Q

3 CNS manifestations of VZV infx

A

1) Cerebellar ataxia
2) Meningitis
Encephalitis

47
Q

infection of a pregnant woman in first 20 weeks of pregnancy carries risk of?

A

Congenital varicella syndrome. = birth defects

48
Q

If get varicella < 5 days before delivery increased risk of ?

A

congenital varicella zoster = disseminated, systemic disease

49
Q

What are the MC sites of Shingles? (3)

A

thoracic, ophthalmic and cervical most common.

50
Q

What are the two main complications of Shingles?,

A

postherpetic neuralgia

herpes zoster ophthalmicus and treatments

51
Q

Tx for shingles

A

Acyclovir, Famciclovir, Valacyclovir treatment best started < 72 hours after first lesion

52
Q

What is Hutchinson’s sign? what does it portend? =

A

Herpes lesions on tip of nose–> higher chance of ocular involvement (herpes zoster ophthalmicus)

53
Q

Tx for herpes zoster ophthalmicus

A

cyclovirs, topical steroids

54
Q

What are the 1st and 2nd MC viruses that cause Bell’s Palsy?

A 
#1 - HSV-1
#2 - VZV
55
Q

What kind of vaccine is the VZV vaccine

A

Live, Attenuated virus vaccine

56
Q

When it should VZV vaccine be given for varicella and when it should be given for zoster

A

varicella (chickenpox)- First dose 12-14 months, second dose 4-6 years
Zoster -(Shingles) - over 60 years old

D&T test 5 - Renal, Urogential (27 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions