Class: Neisseria gonorrhea Flashcards
normal flora of?
respiratory and genital tract
What enzyme is Neisseria positive for q
oxidase
What agar is required for N. gonorrhoeae and N. meningitidis.
Chocolate
Increased concentrations of what chemical is required for N. gonorrhoeae and N. meningitidis growth on chocolate agar?
Increased CO2
What are the cellular antigens of N. gonorrhea (2)? what is the major virulence factor?
LPS = endotoxin
Pili (fimbriae) - major adhesin, major virulence factor
What has been an unsuccessful vaccine target? why hasn’t it worked?
Pili- large strain-to-strain antigenic variation–> no vaccine
What is the exoptoxin of NG
IgA protease
Where does NG live inside host
in PMN cells (Neutrophils, eosinophils, and basophils)
What are infx of males (3)
urethritis, prostatitis, orchitis
Is urethritis painful?
yes
Where does NG infect female
endocervix and rectum
in complicated infx of female with NG what disease
spread to adjacent tissues = PID
Sx of disseminated infx of blood (3)
arthritis, tenosynovitis, dermatitis
Diagnosis in male
Gram stain (urethral exudate only) – Gram (-) diplococci- diagnostic!
what does the home test kit detect
antigens in urine or swab of urethra, cervix
