Diuretics Flashcards
What class of drug is Indapamide?
Thiazide like diuretic
Drugs that are thiazide like diuretics?
Indapamide and Bendroflumethiazide
Indications of Indapamide
Antihypertensive
Mechanism of action of Indapamide
Inhibits Na/Cl co-transporter in the distal tubule
Adverse effects of Indapamide
Hyperuricaemia, Hyperglycaemia, ED, increase in LDL, increase in triglycerides, Hypercalcaemia (favors sodium, calcium channel in the collecting duct). Hypokalaemia (enhanced loss at the collecting duct because more sodium is taken up here)
Contra-indications of Indapamide
Addison’s disease, Hypercalcaemia, Hyponatremia, Refractory hypokalaemia, symptomatic hyperuricaemia
Drug-drug interactions of Indapamide
Alcohol and Amlodipine
Why do you take Indapamide in the morning as a single dose?
So you don’t have to get up in the night to wee
How do you remember Indapamide?
What type of drug class is Spironolactotne?
Potassium sparing diuretic
What are the common indications of Spironolactone?
Heart failure
What is the mechanism of action of Spironolactone?
Mineralocorticoid receptor antagonist ,aldosterone antagonist
What are the adverse drug reactions of Spironolactone?
Gynaecomastia, hyperkalaemia, cutaneous adverse reaction
What are important drug-drug interactions of Spironolactone?
Alcohol, Amiloride and ACEi
How do you remember Spironolactone?
Holding bananas- potassium sparing
Minions won’t drink alcohol (drug-drug interaction)
Together look like two boobs (gynaecomastia)
