Anticoagulants Flashcards
What class of drug is Apixaban?
Direct acting oral anticoagulant (DOAC)
What are the common indications for Apixaban?
DVT or PE
What is the mechanism of action of Apixaban?
Inhibit both free Xa and that bound with ATIII, do not directly affect thrombin (IIa)
Hepatic metabolism and excreted partly by kidneys
What are the adverse effects of Apixaban?
Bleeding and skin reactions
What are the drug-drug interactions of Apixaban?
CYP inhibitors and inducers
Reduced by carbamazepine, phenytoin and barbituates
Increased by macrolides
How do you remember Apixaban?
What class of drug is Dalteparin?
Low molecular weight heparin
What are the drug-drug interactions of Dalteparin?
Other anti-thrombotic drugs, ACEi/ARB, K+ sparing diuretics
What are the common indications for Dalteparin?
Prophylaxis for DVT and PE
What is the mechanism of action of Dalteparin?
Specific inhibition of Xa specifically by enhancing ATIII (natural substance in the body with anticoagulant effects)
What are the adverse effects of Dalteparin?
Bruising and bleeding, intracranial, at site of injection, GI epistaxis. HIT. Hyperkalaemia- inhibiting aldosterone release
How do you remember Dalteparin?
What class of drug is Warfarin?
Vitamin K antagonist
What are the common indications for Warfarin?
Venous thromboembolism, PE, DVT, superficial vein thrombosis
What is the mechanism of action of Warfarin?
Inhibition of vitamin K dependent clotting factors
Inhibits conversion of vitamin K to active reduced form
How do you remember Warfarin?
