Cholesterol-uptake Inhibitors Flashcards

1
Q

What class of drug is Ezetimibe?

A

Selective cholesterol-absorption inhibition

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the indication of Ezetimibe?

A

Hypercholesterolemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the mechanism of action of Ezetimibe?

A

Inhibits NPC1L1 transporter at brush border of small intestine. Hepatic LDL receptor expression increases.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the adverse effects of Ezetimibe?

A

Abdominal pain, GI upset, Angioedema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the drug-drug interactions of Ezetimibe?

A

Statins- risk of rhabdomyolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How is Ezetimibe administered and why?

A

The drug is administered orally, half life of 22 hours.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How do you remember Ezetimibie?

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly