Antiarrhythmics Flashcards
What class of drug is Amiodarone?
Class 3 antiarrhythmic
What are some common indications of Amiodarone?
- Arrhythmias
- Used to treat tachycardia associated with Wolf-Parkinson White syndrome
What is the mechanism of action of Amiodarone?
Prolongs repolarization, action potential by blocking potassium channels
What are some adverse effects of Amiodarone?
- Pulmonary fibrosis
- Hepatic injury
- Increase LDL cholesterol
- Thyroid disease
- Photosensitivity
What are the drug-drug interactions of Amiodarone?
Statins
Why is Amiodarone contra-indicated in thyroid disease?
It has very high levels of iodine
What should you use to remember Amiodarone?
‘Best antiarrhythmic’ like amazon is the best commerce company
Yellow butterfly
Yellow= potassium channel blocker
Butterfly= contra indicated in thyroid disease
What is the effect of Amiodarone on the action potential of the ventricular myocyte?
What class of drug is Flecainide?
Class Ic antiarrhythmic
What is the mechanism of action of Flecainide?
Sodium channel blocker. Slows down automaticity, decreases phase 0. Increases Action Potential and Early repolarisation. Increase in QRS, QT and PR.
What are the common indications for Flecainide?
Supraventricular arrhythmias and Wolf-Parkinson White syndrome.
What are the adverse effects of Flecainide?
Flecainide flutter, proarrhythmia (especially with structural HD, CNS and GI effects. Use an AV node blocker.
What are the drug-drug interactions of Flecainide?
Other anti-arrhythmic drugs (ones that prolong QT)
What would Flecainide do to the action potential of ventricular myocytes?
How do you remember Flecainide?
