Disease AND specific terms - Block 1 Flashcards
Marfan syndrom
- mutation of what
- results in abn what
- physio outcomes in patients (MN)
- fibrillin gene,
- ab elastic fibers
- -elongated limbs
- aortic aneurysms (bulging of the aortic wall)
- dislocation of eye lens
*Marfan is a martian -> long limbs AND aneurysms AND dislocation of eye lens
give three examples of glycoproteins
1 FIBRO-NECTIN
2 laminin
3 C-HONDRO-NECTIN
GAG always has what in its name
sulfate
Proteoglycans
- structure
- purpose
- Core protein with GAGs (sugar) attached along it.
2. provide structure to matrix and hold water.
two types of macromolecules
generated by fibroblasts ARE
glycoproteins
proteoglycans
type I hypersensitivity reactions
1. symptoms
- caused by what (at cellular level)
- example of common type 1 hypers rxn
- swelling and itching
- when mast cells dump its contents in EC space
read: anaphylactic shock results when there’s extensive release of mediators - allergic rxn
if Na channels are blocked, threshold will go (up/down)
up
Bactin
bactin blocks Na channels on pain-sensing neurons
Ca is normally found where
EC
normal REL of Ca with channels
Ca inhibits opening of channels
absolute refractory period coincides with Na channel “”
inactivation
the “” of actin potentials is used to encode info in CNS
frequency
define accomodation in AP
membrane is continuously depolarized -> NaC progressively become inactivated -> accommodation -> results in AP frequency DOWN
define relative refractory period: Na channels and K channels
NaC: no longer inactivated
KC: open
elevation in extracellular K is called
hyper-KALEMIA
changes in EC (ion) can have dire consequence for brain
Na
not K
muscle weakness is a symptom of what two things
Hyper
- calcemia
- kalemia
what ion channel underlies plateau phase
Ca
trigger disease for abnormal neurofilament (pathway)
damaged axon leads to A-MYO-TROPHIC laterla sclerosis
defective keratin in skin causes what and why
this disease is called EPIDERMOLYSIS
causes blisters bc can’t resist pressure
BULLOSA
PROGERIA (premature aging of child) is caused by what
mutation of LAMINA
diseases involving kinesin
anesthetic lidocaine INHIBITS kinesin movement in axons (same as stop forward transport of NT to nerve synapses)
Charcot MT neuropathy; interrupts transport of stuff
Retinitis pigmentosa
Na,K,Cl cotransporter is the target of what thing
diuretic called FURO-SE-MIDE
when inhibit, less water is taken back up and more water goes out in urine (diuresis)
Name two blistering diseases
1 Epiderm Bullosa - mutation in keratin means blistering skin
topo iso merase are targets of what antibiotic
quino lone
ex: cipro floxi cin
