difficult midterm stuff dump

Question 1

what does the M3 receptor do

Answer 1

cause glandular secretion
contract visceral smooth muscle
cause NO mediated vascular relaxation

Question 2

what is tubocuraine

Answer 2

nAChR antagonist

Question 3

what is pilocarpine and what does it treat

Answer 3

mAchR agonist

treats glaucoma

Question 4

what treats sjogrens syndrome

Answer 4

pilocarpine/cevimeline- increases lacrimal and salivary secretion- mAChR

Question 5

motor endplate of voluntary muscle has what receptor and what nT

Answer 5

muscle type nAChR - ACh

Question 6

suxamethonoium is a

Answer 6

depolarizing agent at the NMJ (nAChR agonist)

Question 7

how do depolarizing agents cause persistent depolarization

Answer 7

acetylcholinesterase resistant

Question 8

how do nondepolarizing agents block transmission

Answer 8

competitively

block presynaptic release

Question 9

butyrylcholinesterase acts where

Answer 9

plasma

Question 10

anticholinesterase drugs enhance ACh activity at

Answer 10

parasynpathetic postganglionic synapses = parasympathetic effects

Question 11

• stigmine are

Answer 11

anticholinesterases

Question 12

effects of anticholinesterases

Answer 12

increased secretion, bradycardia, hypotension

because of enhanced ACh activity at parasympathetic postganglionic synapses

Question 13

kinase linked receptors are activated by

Answer 13

protein mediators

Question 14

HREs are for

Answer 14

NR 1

Question 15

phenoxybenzamine is used for

Answer 15

phaeochromocytoma

alpha antagonist

Question 16

what are the 3 alpha antagonists

Answer 16

phenoxybenzamine
prazosin
doxazosin

Question 17

what are the 2 things alpha antagonists are used for

Answer 17

phaeochromocytoma

hypertension

Question 18

NR 1 do what upon ligand binding (2 things)

Answer 18

dimerize and translocate to nucleus

Question 19

paraenteral

Answer 19

bypassing the intestines

Question 20

glutathione is a

Answer 20

tripeptide

Question 21

functionalization step what enzymes

Answer 21

CYP

Question 22

NAT 1 or 2 has genetic polymorphism

Answer 22

2

Question 23

where are NATs found

Answer 23

kupffer cells

Question 24

glutathione conjugation is designed to

Answer 24

inactivate and remove electrophilic species

Question 25

what do we use with acetaminophen to prevent hepatotoxicity

Answer 25

N acetyl cystine | methionine

Question 26

do antagonists have efficacy?

Answer 26

no- only affinity

Question 27

functionalization and conjugation are part of

Answer 27

hepatic metabolism for lipophilic drugs

Question 28

3 amino acids of glutathione

Answer 28

glu-cys-gly

Question 29

are active NOS monomers or dimers

Answer 29

homodimers

Question 30

what does cGMP produced from NO act on

Answer 30

ion channels PKG phosphodiesterases broken down into 5GMP by PDE5

Question 31

nNOS in PNS is a

Answer 31

NANC neurotransmitter

Question 32

glucocorticoids inhibit

Answer 32

iNOS expression

Question 33

CO is made with

Answer 33

heme oxygenase

Question 34

iNOS is made with which WBC

Answer 34

macrophages

Question 35

ADP stimulates platelet aggregation by

Answer 35

P2Y12

Question 36

nitroprusside

Answer 36

hypertensive crisis

Question 37

nitroglycerin (glyceryl trinitrate)

Answer 37

to treat angina

Question 38

alprostadil

Answer 38

PGE2 analogue | vasodilator

Question 39

misoprostol

Answer 39

PGE2 analogue | prevents ulcer formation with NSAID use

Question 40

gemeprost/ misoprostol/ dinoprostone

Answer 40

uterine contraction/ induce labor

Question 41

carboprost

Answer 41

prevents bleeding from delivery (PGF2a analogue)

Question 42

latanoprost

Answer 42

decreases IOP for glaucoma (PGF2a analogue)

Question 43

epoprostenol

Answer 43

PGI2 analogue | treats pulmonary hypertension

Question 44

alpha methyl tyrosine mechanism of action

Answer 44

blocks tyrosine hydroxylase and inhibits NE and E formation

Question 45

when there is competition, there is a ___ in individual collisions but an _____ in overall collisions

Answer 45

decrease in individual | increase in overall

Question 46

plasma protein binding results in

Answer 46

higher drug concentration in plasma, similar free drug conc in plasma and cell

Question 47

ipratropium

Answer 47

mAChR antagonist for COPD and Asthma

Question 48

cytokine function

Answer 48

regulate actions of mmune and inflammatory cells

Question 49

what makes arachidonate into EETs

Answer 49

CYP450

Question 50

where is CB1 found

Answer 50

brain (mostly), endothelial cells, adipocytes, peripheral nerves

Question 51

effect of adenosine, serotonin, ADP, and eNOS on platelets

Answer 51

5HT and ADP = aggregation | adenosine and eNOS = prevent aggregation

Question 52

hexamethonium is

Answer 52

nAChR antagonist

Question 53

what is nabilone

Answer 53

synthetic cannabinoid used in chemotherapy to treat nausea and vomiting