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PHARM 203 > difficult midterm stuff dump > Flashcards

difficult midterm stuff dump Flashcards

1
Q

what does the M3 receptor do

A

cause glandular secretion
contract visceral smooth muscle
cause NO mediated vascular relaxation

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2
Q

what is tubocuraine

A

nAChR antagonist

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3
Q

what is pilocarpine and what does it treat

A

mAchR agonist

treats glaucoma

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4
Q

what treats sjogrens syndrome

A

pilocarpine/cevimeline- increases lacrimal and salivary secretion- mAChR

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5
Q

motor endplate of voluntary muscle has what receptor and what nT

A

muscle type nAChR - ACh

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6
Q

suxamethonoium is a

A

depolarizing agent at the NMJ (nAChR agonist)

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7
Q

how do depolarizing agents cause persistent depolarization

A

acetylcholinesterase resistant

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8
Q

how do nondepolarizing agents block transmission

A

competitively

block presynaptic release

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9
Q

butyrylcholinesterase acts where

A

plasma

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10
Q

anticholinesterase drugs enhance ACh activity at

A

parasynpathetic postganglionic synapses = parasympathetic effects

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11
Q
  • stigmine are
A

anticholinesterases

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12
Q

effects of anticholinesterases

A

increased secretion, bradycardia, hypotension

because of enhanced ACh activity at parasympathetic postganglionic synapses

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13
Q

kinase linked receptors are activated by

A

protein mediators

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14
Q

HREs are for

A

NR 1

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15
Q

phenoxybenzamine is used for

A

phaeochromocytoma

alpha antagonist

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16
Q

what are the 3 alpha antagonists

A

phenoxybenzamine
prazosin
doxazosin

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17
Q

what are the 2 things alpha antagonists are used for

A

phaeochromocytoma

hypertension

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18
Q

NR 1 do what upon ligand binding (2 things)

A

dimerize and translocate to nucleus

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19
Q

paraenteral

A

bypassing the intestines

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20
Q

glutathione is a

A

tripeptide

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21
Q

functionalization step what enzymes

A

CYP

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22
Q

NAT 1 or 2 has genetic polymorphism

A

2

23
Q

where are NATs found

A

kupffer cells

24
Q

glutathione conjugation is designed to

A

inactivate and remove electrophilic species

25
Q

what do we use with acetaminophen to prevent hepatotoxicity

A

N acetyl cystine

methionine

26
Q

do antagonists have efficacy?

A

no- only affinity

27
Q

functionalization and conjugation are part of

A

hepatic metabolism for lipophilic drugs

28
Q

3 amino acids of glutathione

A

glu-cys-gly

29
Q

are active NOS monomers or dimers

A

homodimers

30
Q

what does cGMP produced from NO act on

A

ion channels
PKG
phosphodiesterases
broken down into 5GMP by PDE5

31
Q

nNOS in PNS is a

A

NANC neurotransmitter

32
Q

glucocorticoids inhibit

A

iNOS expression

33
Q

CO is made with

A

heme oxygenase

34
Q

iNOS is made with which WBC

A

macrophages

35
Q

ADP stimulates platelet aggregation by

A

P2Y12

36
Q

nitroprusside

A

hypertensive crisis

37
Q

nitroglycerin (glyceryl trinitrate)

A

to treat angina

38
Q

alprostadil

A

PGE2 analogue

vasodilator

39
Q

misoprostol

A

PGE2 analogue

prevents ulcer formation with NSAID use

40
Q

gemeprost/ misoprostol/ dinoprostone

A

uterine contraction/ induce labor

41
Q

carboprost

A

prevents bleeding from delivery (PGF2a analogue)

42
Q

latanoprost

A

decreases IOP for glaucoma (PGF2a analogue)

43
Q

epoprostenol

A

PGI2 analogue

treats pulmonary hypertension

44
Q

alpha methyl tyrosine mechanism of action

A

blocks tyrosine hydroxylase and inhibits NE and E formation

45
Q

when there is competition, there is a ___ in individual collisions but an _____ in overall collisions

A

decrease in individual

increase in overall

46
Q

plasma protein binding results in

A

higher drug concentration in plasma, similar free drug conc in plasma and cell

47
Q

ipratropium

A

mAChR antagonist for COPD and Asthma

48
Q

cytokine function

A

regulate actions of mmune and inflammatory cells

49
Q

what makes arachidonate into EETs

A

CYP450

50
Q

where is CB1 found

A

brain (mostly), endothelial cells, adipocytes, peripheral nerves

51
Q

effect of adenosine, serotonin, ADP, and eNOS on platelets

A

5HT and ADP = aggregation

adenosine and eNOS = prevent aggregation

52
Q

hexamethonium is

A

nAChR antagonist

53
Q

what is nabilone

A

synthetic cannabinoid used in chemotherapy to treat nausea and vomiting

PHARM 203 (21 decks)

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