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PHARM 203 > 12: Eicosanoids and cannabinoids > Flashcards

12: Eicosanoids and cannabinoids Flashcards

1
Q

are eicosanoids stored in cells

A

no

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2
Q

what are eicosanoids derived from

A

arachidonic acid or similar polyunsaturated acids 20C in length

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3
Q

what are eicosanoids used for

A

inflammation + control physiological processes

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4
Q

first ecosanoids identified

A

prostaglandins

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5
Q

important eicosanoids

A

prostanoids: prostaglandins and thromboxanes
leurotrienes
EETs

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6
Q

arachidonate produces

A

HPETEs + leukotrienes
prostanoids
EETs

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7
Q

which COX is inducible

A

COX2

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8
Q

what produces PGI2

A

PGI2 = prostacyclin

prostacyclin synthase in endothelium

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9
Q

what are the effects of PGI2

A

inhibits platelet aggregation

vasodilator

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10
Q

what prduces TXA2

A

thromboxane synthase

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11
Q

what are the effects of TXA2

A

promotes platelet aggregation and vasoconstriction

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12
Q

what is the main inflammatory mediatory prostaglanding

A

PGE2

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13
Q

receptor for PGD2

A

DP

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14
Q

receptor for PGE2

A

EP

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15
Q

receptor for PGF2alpha

A

FP

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16
Q

receptor for PGI2

A

IP

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17
Q

receptor for TXA2

A

TP

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18
Q

which prostanoid inhibits gastric acid secretion and increases GI mucous secretion

A

PGE2

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19
Q

what causes cervical ripening

A

PGE2

20
Q

what causes uterine contractions

A

PGFalphha

21
Q

what simulates platelet aggregation

A

TXA2

22
Q

leukotrienes are made by

A

WBCs such as macrophages, eosinophils, basophils, and mast cells

23
Q

what are leukotrienes synthesized from

A

arachidonate with lipooxygenase

24
Q

2 receptor types for leukotrienes

A

BLT- LBT4 ligand

CysLT- cysteinyl leukotriene ligand

25
Q

the proinflammatory LTB4 stimulates

A

neutrophil chemotaxis

proliferation and cytokine production by macrophages and lymphocytes

26
Q

cysteinyl leukotrienes reuslt in

A

contraction in bronchial muscle

vasodilation in most vessels + coronary constriction

27
Q

safirlukast and montelukast are used for

A

asthma

CystLT receptor antagonists

28
Q

main psychoactive component of cannabinoids

A

THC

29
Q

what has psychomimetic and depressant effects on the CNS

A

THC

30
Q

CNS effects of cannabinoids

A 
impaired STM, simple learning tasks, and motor coordination
increased appetite
antiemetic
catalepsy
analgesia
31
Q

peripheral effects of cannabinol

A

vasodilation (esp in eyes)
decreased IOP
bronchodilation

32
Q

CB receptors are

A

GPCR

33
Q

what are CB receptors linked to

A

G1/0

34
Q

G1/0 results in

A

inhibiting AC
inhibit voltage gated Ca2+ channels
cause hyperpolarization by rectifying K+ channels

35
Q

where are CB1 receptors found

A

brain (mostly)

also endothelial cells, adipocytes, and peripheral nerves

36
Q

where are CB2 found

A

immune cells

37
Q

endocannabioids are synthesized from

A

membrane phospholipids

38
Q

2 best characterized endocannabinoids

A

anandamide

2-arachidonyl glycerol

39
Q

endocannabinoids are ___ mediators

A

retrograde

40
Q

nabiximols

A

combination of THC and CBD

for pain

41
Q

nabilone

A

synthetic cannabnoid

for nausea and vomitting associated with chemo

42
Q

alprostadil, misoprostol, gemeprost/ misoprostol, and dinoprostone/ misoprostone are

A

PGE2 agonsts

43
Q

pyrogenic means

A

fever inducing

44
Q

alprostadil

A

PGE2 agonist that vasodilates

45
Q

gemeprost/ misoprostol and dinoprostone and misoprostol are used for

A

uterine contraction/ labour induction

PGE2 agonists

46
Q

what is the analogue of prostacyclin

A

epoprostenol

47
Q

carboprost and latanoprost are

A

PGF2alpha agonists

PHARM 203 (21 decks)

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