34: Pulmonary Hypertension

Question 1

pulmonary arterial hypertension is characterized by

Answer 1

elevated pulmonary artery pressures

Question 2

elevated pulmonary vascular resistance results in remodelling of the _____ ventricle

Answer 2

right

Question 3

no known cause, rate, severe form

Answer 3

idiopathic PAH

Question 4

familial PAH

Answer 4

mutations in Bmpr2 gene

Question 5

secondary PAH

Answer 5

associated with other medical conditions

Question 6

-entan are

Answer 6

endothelin receptor antagonists

Question 7

sitaxentan blocks

Answer 7

SMC ETa receptors

Question 8

-prost-

Answer 8

prostacyclina nd analogues

Question 9

prostacyclin MOA

Answer 9

binds SMC IP receptors and increase cAMP- AC activators

Question 10

what drugs cause the largest reductions in pulmonary artery pressure

Answer 10

prostacyclins

Question 11

riociguat

Answer 11

allosteric sGC activator
increases cGMP signalling
potentiates action of NO + causes vasodilation

Question 12

what is an sGC activator

Answer 12

riociguat

Question 13

is inhaled NO used for PAH

Answer 13

no

Question 14

what is inhaled NO used for

Answer 14

acute vasodilator testing of PAH

treat pulmonary hypertensive crises in newborns

Question 15

what is “shock”

Answer 15

inadequate perfusion of vital organs
low arterial bp
leads to anaerobic metabolism

Question 16

what to give in shock and hypotensive states

Answer 16

fluid replacement
adrenergic vasopressors (E, NE, dobutamine)
ADH

Question 17

what is used in cardiogenic shock to increase CO (B1 effects)

Answer 17

dobutamine