Diagnostic Agents Flashcards
Agent used in certain diagnostic radiographic tests to enable pathological conditions, such as tumors, stones, or blockages, to become visible on an x-ray; high-density pharmcological agents used to visualize low-contrast body tissues that include vascular structures, the urinary bladder, kidneys, the gastrointestinal tract, and the biliary tree
Radiopaque contrast media (ROCM)
Characteristic of contrast media in which the substance does not permit the x-rays to pass through
Radiopaque
solutions that color or mark tissue for identification
Dyes
Solution that is used in surgery to help to differentiate normal from abnormal tissue. _
Staining Agent
All contrast media contain ____________; therefore a thorough patient history of allergies or reactions to _____________ must be obtained and noted in the chart.
Iodine
First generation ROCM that is used mainly in the GU tract for visualizing a stone/blockage or the bladder. This Contrast media can be instilled through a urethral catheter or IV.
Hypaque-76
A second generation contrast media. This water-soluble iodine-based radiographic contrast medium used for angiography, excretory urography, and myelography. It is also less likely to have adverse reactions that first generation Contrast medias. This is one of few ROCM to be approved by the FDA for intrathecal use.
Omnipaque
Dye is inserted via the ureter & injected up the urinary tract. Fluid runs in & back our & is used as a diagnostic flow. This procedure can use iodine based dyes on patients with iodine allergies.
Retrograde Pyelogram (RPG)
radiographic image the biliary tree including the gall bladder and common bile duct
choliangiogram
The duct that carries bile from the gallbladder and liver to the small intestine (duodenum). It is made up of 3 hepatic ducts & 1 Cystic Duct.
Common Bile Duct
The duct that leads from the liver to the common bile duct; transports bile.
Hepatic Duct
Duct leading from the gallbladder to the common bile duct; carries bile
Cystic Duct
a staining dye/indicator that interacts with nucleic acid molecules and proteins, turning them to a very dark blue color. Often used on procedures pertaining to the urinary bladder, uterus, or fallopian tubes. This dye is given IV and excreted in urine.
Methylene Blue
Blue dye used in urologic surgery cases and is not metabolized by the liver. This causes it to be excreted by the kidneys unchanged in the urine.
Indigo Carmine
-Purple dye
-Used in surgery to mark incision lines
-Available in pens
-Useful in plastic & reconstructive surgery
-Topically it’s good to treat fungal infections inside the mouth -thrush, vagina -yeast infections & on the skin
Gentian Violet
This solution has a strong iodine mixture used to perform Schiller tests on cervical tissue. The solution is then applied to the suspect area of the external cervical os with a sponge stick. Abnormal cells will not take up the brown iodine stain as readily as normal cells.
Lugol Solution
This solution has a weaker concentration of iodine and is used as a staining agent. Most often used on the cervix to detect abnormal cells.
Schiller’s Solution
This solution is used to stop patient bleeding after medical procedures. It is a hemostatic agent.
Monsel’s Solution
Although this is not specifically a colored staining agent, This staining agent causes abnormal tissue to appear whiter than surrounding healthy tissue.
Acetic Acid (Vinegar)
What four contrast media agents are frequently used in surgery ?
Hypaque , Omnipaque , Isovue and Visipaque
Cerebral angiography, peripheral arteriography, venography, urography, arthrography, CT enhancement and CECT head and body imaging
Isovue
Four common dyes used in surgery
Methylene blue, Lymphazurin , indigo carmine , gentian violet
What happens to abnormal cervical tissue when Lugol solution is applied?
Nothing- it won’t take up the brown iodine stain. Healthy tissue stains however.
Used for sentinel node biopsy for breast tumors.
Isosulfan blue
Current way to treat nephrotoxicity
Hydration
What is the premedication protocol for patients with a sensitivity to iodine?
Prednisone and diphenhydramine
What variations of angiography uses omnipaque?
Angiocardiography, aortography, peripheral arteriography
Dyes are administered in which ways?
Intravenously, topically and by instilling them into body cavities.
During chromotubation, or tubal dye study, Methylene blue is administered where?
Into the uterus; the dye enters the Fallopian tubes and is observed exiting into the pelvic cavity.
Reasons against giving a particular drug
Contraindicated