Diabete Type 2 Flashcards

0
Q

Physiopathologie DT2

A

Insulinorésistance -> insulinopenie relative

Rôle prédispo génétique ++

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1
Q

Épidémiologie DT2

A

80-90% des diabètes, 10% des >60 ans,

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2
Q

Clinique DT2

A

Sd cardinal, amaigrissement, prurit vulvaire/balanite, infections récidivantes

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3
Q

Dépistage DT2

A

Tous les 3 ans si >40 ans, tous les ans si FR (IMC>27, atcd fam, HTA, HTG>2g/L ou HDL<0,35g/L, gly élevée connue, obésité abdo)

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4
Q

Cible HbA1c DT2

A

<7% (6,5% au début, 8% si complications)

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5
Q

Stratégie thérapeutique DT2

A
RHD
\+ Metformine 
\+ sulfamide/glp1ago/gliptine
\+ -AG/gliptine/glp1/insuline
Si échec repassage biothérapie+insuline
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6
Q

Indication bypass chez le diabétique

A

Traitement >1 an + IMC > 35 + résistance traitement bien conduit

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7
Q

CI metformine

A

Examen iodé, insuffisance viscérale, très âgé

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8
Q

EI metformine

A

Acidose lactique

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9
Q

Action metformine

A

Hypoglycémiant sans hypoglycémie.
Après repas
Svt mal toléré au début

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10
Q

Sulfamide action et EI

A

1 le matin, HYPOGLYCÉMIE, prise 3kg

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11
Q

Glp1ago action et EI

A

Satietogene, bien chez obèse, perte 3kg

EI: aggrave pancréatite préexistante cher

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12
Q

Gliptide EI

A

= inhibiteur DPP4
EI ORL, besoin fonction résiduelle
Bien chez vieux et IRnC

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13
Q

Inhibiteurs alphaglucosidase action

A

Agit sur glycémie post prandiale, bcp intolerance

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