Dermatopathology: Inflammatory Disorders Flashcards
Syndrome of dermal edema due to mast cell degranulation
Uritcaria
Urticaria involves edema in this skin layer
Dermis
What causes urticaria?
Mast cell degranulation (which causes dermal edema)
What is the typical age of a patient with Urticaria?
Any age, peak age 20-40 years old
Who is more likely to have Urticaria, male or female?
Female > male (2:1 ratio)
Urticaria types involving the immune system exhibit this type of hypersensitivity
Type 1
Are IgE dependent
Type of Urticaria that is commonly acute
IgE dependent types
What triggers the IgE dependent types of Urticaria?
Allergic triggers (e.g. food, insect bites, parasites, drugs)
What type of Urticaria involves mast cell degranulation?
Both IgE dependent and independent types
Type of Urticaria that is typically acute but may become chronic
IgE independent types
Hives –> eventual epidermal hyperplasia, fibrosis, lichenification
Where on the body does Urticaria occur?
In areas of pressure, vibration, or exposure to agent
Dermographism (stroking causes wheal reaction) occurs in these 2 conditions
Urticaria and Cutaneous mastocytosis
What is dermographism?
Stroking causing wheal reaction
As seen in urticaria
When does Urticaria resolve?
Within 30 minutes
Transient rapidly edematous papules/plaques
Superficial dermal edema
Well-defined
Wheals (aka hives)
Edematous papules/plaques in deeper dermis and subcutaneous
Less well defined and lack erythema
Angioedema
Does this describe Wheals or Angioedema:
Superficial dermal edema
Wheals
Does this describe Wheals or Angioedema:
Deeper dermis and subcutaneous
Angioedema
Does this describe Wheals or Angioedema:
Raised erythematous
Wheals
Does this describe Wheals or Angioedema:
Lack erythema
Angioedema
Does this describe Wheals or Angioedema:
Well-defined
Wheals
Does this describe Wheals or Angioedema:
Less well defined
Angioedema
Angioedema without wheals may be caused by this
Hereditary C1 esterase inhibitor deficiency
Hereditary C1 esterase inhibitor deficiency may cause this
Angioedema without wheals