Dermatology Flashcards
Which derm disorder is characterized by “itch-scratch cycle”
Atopic dermatitis
Which sites does atopic dermatitis (eczema) appear in most commonly
- Cheeks, scalp, extensor surface of limbs in INFANTS
- Flexural surfaces, hand and feet in CHILD/ADULT
Sharply defined “coin shaped” lesions esp. on dorsal hand, feet, and extensor surface (knees and elbows)
Nummular eczema
Treatment for atopic dermatitis
- Emollients: Vaseline is gold standard
- brief duration of topical steroid during exacerbation
Wickham striae
- lacy lesions of the oral mucosa associated with lichen planus
Common areas of presentation for lichen planus
- Mouth, wrists, back, shin, scalp, penis
Clinical manifestation of lichen planus
- 4 P’s
- Pruritic
- Purple
- Papule
- Polygonal
Which derm condition is associated with a herald patch (solitary salmon-colored macule) on trunk
Pityriasis rosea
Describe clinical manifestation of Pityriasis rosea
- Herald patch on trunk
- 1-2 weeks later, develop smaller, round salmon colored papules
- Christmas tree pattern
- pruritic
Tx for Pityriasis rosea
- Oral antihistamine for itch
- medium strength topical corticosteroids
Most common drug induced skin eruption
Morbilliform
A skin disorder characterized by target (iris) shaped lesions
Erythema multiforme
What is a type 1 hypersensitivity reaction
- IgE mediated causing mast cells to release histamine
Cause of urticaria is the release of
Histamine from mast cells
Are urticaria blanchable
Yes
What is a type IV hypersensitivity reaction
- Delayed type hypersensitivity: takes 2-3 days to develop
- cell mediated
- CD4 + helper T cells recognize antigen in a complex with class 2 MHC on macrophages
What is the most common infectious cause of erythema mulitforme
- Herpes simplex virus
Which drugs are associated with erythema multiforme lesions
- Sulfa drugs
Differentiate between erythema multiforme minor and major
- Both: hypersensitivity reaction characterized by typical targets or raised edematous papules and <10% TBSA involvement
- Major: involvement of 1 or more mucosal sites
- Minor: no involvement of mucosal sites
- ** less severe form of SJS
Most common causes of steven johnson syndrome and toxic epidermal necrolysis
- Sulfa
- anticonvulsant meds
Differentiate between SJS and TEN
- SJS: <10% of total body surface area involved
- TEN: >30% TBSA involved
Bacteria that causes acne
- Proprionibacterium acnes
Oral abx used for treatment of moderate acne
- Doxycycline
- minocycline
Adapalene
- Topical retinoid
- used in treatment of acne