dermatologie Flashcards

1
Q

cause of hyperpigmentation

A
SPARED
sunlight
pregnancy
addison 's disease
renal failure
excess iron(hemochromatosis)
drugs
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2
Q

drugs causing hyperpigmentation

A
busulfan
amiodarone
minocycline
chloroquine
gold
chlorpromazine
bleomycin
5-FU
daunorubicin
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3
Q

gell and coombs classification of hypersensitivity reactions(4)

A

anaphylactic type 1
cytotoxic type 2
immune complex type 3
delayed type 4

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4
Q

gell and coombs classification of hypersensitivity reactions(4)

A

anaphylactic type 1
cytotoxic type 2
immune complex type 3
delayed type 4

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5
Q

quid of allergic triad(3)

A

atopic dermatidis
asthma
hay fever

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6
Q

example of type 1 hypersensitivity(2)

A

anaphylaxis
asthma
local wheal and flare

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7
Q

link between hypersensitivity type 1 ,2 et 3

A

all are antibody mediated

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8
Q

antibody involved in anaphylaxis reaction

A

IGE

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9
Q

reaction of type 2 hypersensitivity example(4)

A

autoimmune hemolytic anemia
erythroblastosis fetalis
goodpasture
rheumatic fever

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10
Q

Ig involed in type 2(2)

A

IG G

IG M

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11
Q

action in type 2 (2)

A

immunoglobin binds to enemy cell

lysis is done by complement or phagocytosis

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12
Q

MAC

A

membrane attack complex

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13
Q

in what reaction you have MAC

A

2

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14
Q

type 3 hypersensitivity

A

immun complex mediated

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15
Q

example of type 3(6)

A
PAN
immune complex glomerulonephritis
SLE
rheumatoid arthritis
serum sickness
arthus reaction
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16
Q

example of type 3(4)

A

PAN
immune complex glomerulonephritis
SLE
rheumatoid arthritis

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17
Q

example of arthus reaction(2)

A

hypersensitivity pneumonitis

thermophilic actinomycetes

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18
Q

most common cause of serum sickness

A

drugs

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19
Q

mechanism of type 4 hypersentivity

A

sensitised T lymphocytes

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20
Q

example of type 4(3)

A

TB skin test
transplant rejection
contact dermatidis

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21
Q

physiopatho of bullous pemphigoid

A

autoantibodies against BP1 and BP2

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22
Q

where you find protein BP1 and BP 2

A

basement membrane of the skin

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23
Q

rx of pemphigoid(3)

A

steroids
oral pour severe cases
topic for mild case

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24
Q

bulle in P vulgaris

A

painful

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25
Q

bulle in Pemphigoid

A

itchy

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26
Q

localisation of blister in P vulgaris(2)

A

intraepidermal

shallow

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27
Q

localisation of blister in bullous pemphigoid (2)

A

subepidermal

deep

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28
Q

patient with reccurent erythema multiforme

A

HSV infection

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29
Q

dichotomy of NSAIDS(2)

A

precipitating factor

rx for erythema nodosum

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30
Q

disease associated with lichen planus

A

HCV

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31
Q

4 P for lichen planus

A

polygonal
purple
pruritic
papule

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32
Q

wickam striae

A

surface of skin is shiny and reveals fine white lines

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33
Q

physiopatho of psoriasis

A

T cell mediated problem

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34
Q

quid of overlap SJS TEN

A

involvement of 10 a 30% of BSA

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35
Q

leading cause of death in SJS TEN early stage

A

staph aureus infection

36
Q

leading cause of death in SJS TEN late stage

A

pseudomonas

37
Q

isotretinoin and pregnancy

A

teratogenic

38
Q

cause of hot tub foliculitis

A

pseudomonas aeruginosa

39
Q

kerion(2)

A

inflammatory

granulomatous reaction of the scalp in kid

40
Q

cause of kerion

A

tinea capitis

41
Q

2 types of impetigo

A

non bullous

bullous

42
Q

physiopatho of impetigo

A

coagulase +staphylococci producing exfoliatin

43
Q

lice bugs(3)

A

pediculus capitis
pediculus corporis
phtyrus pubis

44
Q

erythema infectyosum(2)

A

slapped cheek first

maculopapular rash on trunk and extremities 1-2 days later

45
Q

bug causing erythema infectyosum(2)

A

parvovirus B 19

fifth disease

46
Q

chicken pox rash(2)

A

clear vecicle on erythematous base=

dewdrop on a rose petal

47
Q

scarlet fever(3)

A

sabd paper like rash on the trunks
strawberry tongue
circumoral pallor

48
Q

wil you have desquamation in scarlet fever

A

after a few days

49
Q

rocky spotted mountain fever(2)

A

rask on palms and soles

spread on trunk and face later

50
Q

cause of rocky mountain spotted fever

A

tick bite

51
Q

Lyme disease

A

erythema chronicum migrans

52
Q

quid of erythema chronicum migrans

A

circular lesion with central clearing

53
Q

bull’s eye appearance

A

lyme disease

54
Q

zone bastion de lyme(4)

A

axillae
behind knees
inguinal area
moist sites

55
Q

causes of cervical cancer

A

HPV 16,18,31,33

56
Q

triad of tuberous sclerosis(3)

A

thickened areas of skin
hypopigmentation
angiofibromas

57
Q

quid of shagreen patches in tuberous sclerosis

A

thickened areas of skin

58
Q

quid of ash leaf spots

A

hypopigmentation intuberous sclerosis

59
Q

localisation of angiofibromas

A

red papules around nose

60
Q

non skin disease associated with tuberous sclerosis(4)

A

seizures
mental retardation
kidney or heart tumors
periventricular tubers

61
Q

non dermatologic manif of neurofibromatosis(6)

A
meningiomas
acoustic neuromas
optic nerve gliomas
renovascular hTA
scoliosis
seizures
62
Q

cutaneous manif of stuge weber

A

port wine stain of the face over the distribution of CN 5 (1)=hemangioma

63
Q

non dermatologic manif of of sturge weber(3)

A

seizures
mental retardation
visual impairement

64
Q

non dermatologic manif of von hippel lindau(4)

A

retinal vascular hamartomas
renal cell cancer
pheo
polycythemia

65
Q

meaning of lesertrelat

A

gastric cancer

66
Q

risk in actinic keratosis

A

SCC

67
Q

4 types of melanoma

A

superficial spreading
nodular
acral lentiginous
lentigo maligna

68
Q

70 % of all melanomas

A

superficial spreading

69
Q

characteristics of superficial spreading melanomas

A

ABCD

70
Q

age for superficial spreading melanomas(2)

A

30-50 ans

M=F

71
Q

appearance of nodular melanoma

A

blue berry like nodule

72
Q

characteristics of nodular melanoma

A

arises rapidly

73
Q

age for nodular melanoma(2)

A

50

M=F

74
Q

acral lentiginous

A

marked variegation of brown black papule or macule

75
Q

zone bastion de acral lentiginous(4)

A

palms
soles
mucous membranes
nails

76
Q

quid of lentigo maligna(2)

A

flat geographic shape

brown black with stain like appearance

77
Q

zone bastion of lentigo maligna

A

sun exposed area

78
Q

epidemio of acral lentiginous(3)

A

60
M>F
asians and african americans

79
Q

epidemio of lentigo maligna(3)

A

60
M=F
fair skinned

80
Q

mycosis fungoides

A

a T cell lymphoma cutane

81
Q

vesicles on back of the neck during intake of infliximab

A

zoster infection

82
Q

quid of lesertrelat sign

A

numerous seborrheic keratosis

83
Q

disease with wickam striae

A

lichen planus

84
Q

cutaneoaus manif of von hippel lindau

A

hemangiomas

85
Q

rx of P vulgaris(4)

A

hospitalisation
systemic corticosteroids
immunosuppression
plasmapheresis

86
Q

corticosteroid in rosacea

A

contreindicated

87
Q

rhinophyma

A

nose tissue hypertrophy in rosacea