dermatologie Flashcards

1
Q

cause of hyperpigmentation

A
SPARED
sunlight
pregnancy
addison 's disease
renal failure
excess iron(hemochromatosis)
drugs
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2
Q

drugs causing hyperpigmentation

A
busulfan
amiodarone
minocycline
chloroquine
gold
chlorpromazine
bleomycin
5-FU
daunorubicin
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3
Q

gell and coombs classification of hypersensitivity reactions(4)

A

anaphylactic type 1
cytotoxic type 2
immune complex type 3
delayed type 4

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4
Q

gell and coombs classification of hypersensitivity reactions(4)

A

anaphylactic type 1
cytotoxic type 2
immune complex type 3
delayed type 4

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5
Q

quid of allergic triad(3)

A

atopic dermatidis
asthma
hay fever

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6
Q

example of type 1 hypersensitivity(2)

A

anaphylaxis
asthma
local wheal and flare

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7
Q

link between hypersensitivity type 1 ,2 et 3

A

all are antibody mediated

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8
Q

antibody involved in anaphylaxis reaction

A

IGE

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9
Q

reaction of type 2 hypersensitivity example(4)

A

autoimmune hemolytic anemia
erythroblastosis fetalis
goodpasture
rheumatic fever

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10
Q

Ig involed in type 2(2)

A

IG G

IG M

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11
Q

action in type 2 (2)

A

immunoglobin binds to enemy cell

lysis is done by complement or phagocytosis

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12
Q

MAC

A

membrane attack complex

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13
Q

in what reaction you have MAC

A

2

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14
Q

type 3 hypersensitivity

A

immun complex mediated

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15
Q

example of type 3(6)

A
PAN
immune complex glomerulonephritis
SLE
rheumatoid arthritis
serum sickness
arthus reaction
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16
Q

example of type 3(4)

A

PAN
immune complex glomerulonephritis
SLE
rheumatoid arthritis

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17
Q

example of arthus reaction(2)

A

hypersensitivity pneumonitis

thermophilic actinomycetes

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18
Q

most common cause of serum sickness

A

drugs

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19
Q

mechanism of type 4 hypersentivity

A

sensitised T lymphocytes

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20
Q

example of type 4(3)

A

TB skin test
transplant rejection
contact dermatidis

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21
Q

physiopatho of bullous pemphigoid

A

autoantibodies against BP1 and BP2

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22
Q

where you find protein BP1 and BP 2

A

basement membrane of the skin

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23
Q

rx of pemphigoid(3)

A

steroids
oral pour severe cases
topic for mild case

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24
Q

bulle in P vulgaris

A

painful

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25
bulle in Pemphigoid
itchy
26
localisation of blister in P vulgaris(2)
intraepidermal | shallow
27
localisation of blister in bullous pemphigoid (2)
subepidermal | deep
28
patient with reccurent erythema multiforme
HSV infection
29
dichotomy of NSAIDS(2)
precipitating factor | rx for erythema nodosum
30
disease associated with lichen planus
HCV
31
4 P for lichen planus
polygonal purple pruritic papule
32
wickam striae
surface of skin is shiny and reveals fine white lines
33
physiopatho of psoriasis
T cell mediated problem
34
quid of overlap SJS TEN
involvement of 10 a 30% of BSA
35
leading cause of death in SJS TEN early stage
staph aureus infection
36
leading cause of death in SJS TEN late stage
pseudomonas
37
isotretinoin and pregnancy
teratogenic
38
cause of hot tub foliculitis
pseudomonas aeruginosa
39
kerion(2)
inflammatory | granulomatous reaction of the scalp in kid
40
cause of kerion
tinea capitis
41
2 types of impetigo
non bullous | bullous
42
physiopatho of impetigo
coagulase +staphylococci producing exfoliatin
43
lice bugs(3)
pediculus capitis pediculus corporis phtyrus pubis
44
erythema infectyosum(2)
slapped cheek first | maculopapular rash on trunk and extremities 1-2 days later
45
bug causing erythema infectyosum(2)
parvovirus B 19 | fifth disease
46
chicken pox rash(2)
clear vecicle on erythematous base= | dewdrop on a rose petal
47
scarlet fever(3)
sabd paper like rash on the trunks strawberry tongue circumoral pallor
48
wil you have desquamation in scarlet fever
after a few days
49
rocky spotted mountain fever(2)
rask on palms and soles | spread on trunk and face later
50
cause of rocky mountain spotted fever
tick bite
51
Lyme disease
erythema chronicum migrans
52
quid of erythema chronicum migrans
circular lesion with central clearing
53
bull's eye appearance
lyme disease
54
zone bastion de lyme(4)
axillae behind knees inguinal area moist sites
55
causes of cervical cancer
HPV 16,18,31,33
56
triad of tuberous sclerosis(3)
thickened areas of skin hypopigmentation angiofibromas
57
quid of shagreen patches in tuberous sclerosis
thickened areas of skin
58
quid of ash leaf spots
hypopigmentation intuberous sclerosis
59
localisation of angiofibromas
red papules around nose
60
non skin disease associated with tuberous sclerosis(4)
seizures mental retardation kidney or heart tumors periventricular tubers
61
non dermatologic manif of neurofibromatosis(6)
``` meningiomas acoustic neuromas optic nerve gliomas renovascular hTA scoliosis seizures ```
62
cutaneous manif of stuge weber
port wine stain of the face over the distribution of CN 5 (1)=hemangioma
63
non dermatologic manif of of sturge weber(3)
seizures mental retardation visual impairement
64
non dermatologic manif of von hippel lindau(4)
retinal vascular hamartomas renal cell cancer pheo polycythemia
65
meaning of lesertrelat
gastric cancer
66
risk in actinic keratosis
SCC
67
4 types of melanoma
superficial spreading nodular acral lentiginous lentigo maligna
68
70 % of all melanomas
superficial spreading
69
characteristics of superficial spreading melanomas
ABCD
70
age for superficial spreading melanomas(2)
30-50 ans | M=F
71
appearance of nodular melanoma
blue berry like nodule
72
characteristics of nodular melanoma
arises rapidly
73
age for nodular melanoma(2)
50 | M=F
74
acral lentiginous
marked variegation of brown black papule or macule
75
zone bastion de acral lentiginous(4)
palms soles mucous membranes nails
76
quid of lentigo maligna(2)
flat geographic shape | brown black with stain like appearance
77
zone bastion of lentigo maligna
sun exposed area
78
epidemio of acral lentiginous(3)
60 M>F asians and african americans
79
epidemio of lentigo maligna(3)
60 M=F fair skinned
80
mycosis fungoides
a T cell lymphoma cutane
81
vesicles on back of the neck during intake of infliximab
zoster infection
82
quid of lesertrelat sign
numerous seborrheic keratosis
83
disease with wickam striae
lichen planus
84
cutaneoaus manif of von hippel lindau
hemangiomas
85
rx of P vulgaris(4)
hospitalisation systemic corticosteroids immunosuppression plasmapheresis
86
corticosteroid in rosacea
contreindicated
87
rhinophyma
nose tissue hypertrophy in rosacea