dermatologie Flashcards
cause of hyperpigmentation
SPARED sunlight pregnancy addison 's disease renal failure excess iron(hemochromatosis) drugs
drugs causing hyperpigmentation
busulfan amiodarone minocycline chloroquine gold chlorpromazine bleomycin 5-FU daunorubicin
gell and coombs classification of hypersensitivity reactions(4)
anaphylactic type 1
cytotoxic type 2
immune complex type 3
delayed type 4
gell and coombs classification of hypersensitivity reactions(4)
anaphylactic type 1
cytotoxic type 2
immune complex type 3
delayed type 4
quid of allergic triad(3)
atopic dermatidis
asthma
hay fever
example of type 1 hypersensitivity(2)
anaphylaxis
asthma
local wheal and flare
link between hypersensitivity type 1 ,2 et 3
all are antibody mediated
antibody involved in anaphylaxis reaction
IGE
reaction of type 2 hypersensitivity example(4)
autoimmune hemolytic anemia
erythroblastosis fetalis
goodpasture
rheumatic fever
Ig involed in type 2(2)
IG G
IG M
action in type 2 (2)
immunoglobin binds to enemy cell
lysis is done by complement or phagocytosis
MAC
membrane attack complex
in what reaction you have MAC
2
type 3 hypersensitivity
immun complex mediated
example of type 3(6)
PAN immune complex glomerulonephritis SLE rheumatoid arthritis serum sickness arthus reaction
example of type 3(4)
PAN
immune complex glomerulonephritis
SLE
rheumatoid arthritis
example of arthus reaction(2)
hypersensitivity pneumonitis
thermophilic actinomycetes
most common cause of serum sickness
drugs
mechanism of type 4 hypersentivity
sensitised T lymphocytes
example of type 4(3)
TB skin test
transplant rejection
contact dermatidis
physiopatho of bullous pemphigoid
autoantibodies against BP1 and BP2
where you find protein BP1 and BP 2
basement membrane of the skin
rx of pemphigoid(3)
steroids
oral pour severe cases
topic for mild case
bulle in P vulgaris
painful
bulle in Pemphigoid
itchy
localisation of blister in P vulgaris(2)
intraepidermal
shallow
localisation of blister in bullous pemphigoid (2)
subepidermal
deep
patient with reccurent erythema multiforme
HSV infection
dichotomy of NSAIDS(2)
precipitating factor
rx for erythema nodosum
disease associated with lichen planus
HCV
4 P for lichen planus
polygonal
purple
pruritic
papule
wickam striae
surface of skin is shiny and reveals fine white lines
physiopatho of psoriasis
T cell mediated problem
quid of overlap SJS TEN
involvement of 10 a 30% of BSA