DERM - Benign skin tumors Flashcards
what is leser trelat sign? what does it mean?
- sudden onset of numerous SKs
- may indicate an underlying visceral malignancy
what is the morphology of an acrochordon (skin tag)?
fibrovascular core covered by benign squamous epithelium
cyst with a punctum?
epidermoid cyst
presentation: single subcutaneous nodule at birth on lateral aspect of upper eyelid
dermoid cyst
what is the cause of cowdens disease?
AD mutation of PTEN
what is the presentation for cowdens disease?
- oral lesions
- acral keratoses
- macrocephaly
- trichilemmoma** (diagnostic)
cowdens disease carries a risk of cancer in what organs?
- breast
- thyroid
ghost cells are characteristic of _____________–
pilomatrixoma
fibrofolliculomas, trichodiscomas, acrochordons - diagnosis?
birt-hogg-dube syndrome
what is important to know about nevus sebaceous?
they are benign, but secondary tumors can arise within
yellowish dome shaped papules with central punctum?
sebaceous hyperplasia
what skin condition is seen in muir-torre syndrome?
sebaceous adenoma
muir torre syndrome is related to what cancer syndrome?
HNPCC
what is the inherited defect in muir torre syndrome? what is the inheritance?
- defect in DNA mismatch repair gene
- AD
what are the cutaneous findings in muir torre? visceral?
- cutaneous: sebaceous tumors (adenomas, sebaceoma, carcinoma, keratoacanthoma)
- visceral: GI, bladder, endometrium, breast
