DERM - Basal and squamous cell carcinoma Flashcards
pearly papules often containing prominent, dilated subepidermal blood vessels (telangiectasias) - diagnosis?
BCC
what is the treatment for BCC?
- excision / destruction
BCC can take on what forms?
- rolled borders with ulceration and telangiectasias
- nodular
- morpheaform (scar-like, aggressive)
what is the histology for BCC?
- blue islands in dermis usually attached to epidermis
- peripheral palisading
- stromal retraction
histology:
- blue islands in dermis usually attached to epidermis
- peripheral palisading
- stromal retraction
BCC
what is the familial form of BCC? what is the inheritance?
- gorlin syndrome
- AD
what is the pathogenesis of gorlin syndrome?
- mutation of PTCH gene on chromosome 9
- PTCH is a tumor suppressor - mutation allows SHH signaling pathway to stimulate cell growth
can immunosuppression lead to BCC or SCC?
SCC
SCC often arises in association with what other condition?
actinic keratoses
what is a marjolin ulcer?
SCC in site of previous burn
terminology: SCC in site of pervious burn
marjolin ulcer
risk of SCC metastasis increases with what 4 factors?
- size over FOUR (4) cm
- depth of invasion
- neurotropism
- acantholytic pattern
RAPIDLY DEVELOPING flesh colored dome shaped nodules with a central, keratin filled plug imparting a CRATER LIKE TOPOGRAPHY
- sun exposed area
- older people
- rapidly forming
keratoacanthoma
actinic keratosis displays what type of abnormal growth?
squamous dysplasia
bowenoid papulosis is a variant of _______
SCCIS
bowenoid papulosis is related to what virus?
HPV
multiple small reddish brown papules in anogenital region of a sexually active male?
bowenoid papulosis
merkel cell tumors are of what origin?
neuroendocrine
sheets of tumor cells completely invading dermis?
merkel cell carcinoma
metastatic tumors to the skin come most commonly from what organ in males? females?
- males: lung
- females: breast
what is the sister mary joseph nodule?
umbilical nodule related to a visceral malignancy (stomach, pancreas)
mammary paget’s disease is almost always associated with underlying ___________
mammary ductal carcinoma
- pleomorphic spindle cell tumor with increased mitotic activity
- sun exposed area
- elderly
- firm solitary nodule with or without ulceration
AFX (atypical fibroxanthoma)
what are the 3 settings for angiosarcoma?
- idiopathic
- lymphedema associated
- post-irradiation
what are the 4 types of kaposi sarcoma?
- classic (endemic): distal extremities of mediterranean / Jewish populations
- AIDS related: skin and mucosal surfaces
- immunosuppression related
- african sub saharan
