DERM - Basal and squamous cell carcinoma

Question 1

pearly papules often containing prominent, dilated subepidermal blood vessels (telangiectasias) - diagnosis?

Answer 1

BCC

Question 2

what is the treatment for BCC?

Answer 2

• excision / destruction

Question 3

BCC can take on what forms?

Answer 3

• rolled borders with ulceration and telangiectasias
• nodular
• morpheaform (scar-like, aggressive)

Question 4

what is the histology for BCC?

Answer 4

• blue islands in dermis usually attached to epidermis
• peripheral palisading
• stromal retraction

Question 5

histology:

• blue islands in dermis usually attached to epidermis
• peripheral palisading
• stromal retraction

Answer 5

BCC

Question 6

what is the familial form of BCC? what is the inheritance?

Answer 6

• gorlin syndrome

- AD

Question 7

what is the pathogenesis of gorlin syndrome?

Answer 7

• mutation of PTCH gene on chromosome 9

- PTCH is a tumor suppressor - mutation allows SHH signaling pathway to stimulate cell growth

Question 8

can immunosuppression lead to BCC or SCC?

Answer 8

SCC

Question 9

SCC often arises in association with what other condition?

Answer 9

actinic keratoses

Question 10

what is a marjolin ulcer?

Answer 10

SCC in site of previous burn

Question 11

terminology: SCC in site of pervious burn

Answer 11

marjolin ulcer

Question 12

risk of SCC metastasis increases with what 4 factors?

Answer 12

• size over FOUR (4) cm
• depth of invasion
• neurotropism
• acantholytic pattern

Question 13

RAPIDLY DEVELOPING flesh colored dome shaped nodules with a central, keratin filled plug imparting a CRATER LIKE TOPOGRAPHY

• sun exposed area
• older people
• rapidly forming

Answer 13

keratoacanthoma

Question 14

actinic keratosis displays what type of abnormal growth?

Answer 14

squamous dysplasia

Question 15

bowenoid papulosis is a variant of _______

Answer 15

SCCIS

Question 16

bowenoid papulosis is related to what virus?

Answer 16

HPV

Question 17

multiple small reddish brown papules in anogenital region of a sexually active male?

Answer 17

bowenoid papulosis

Question 18

merkel cell tumors are of what origin?

Answer 18

neuroendocrine

Question 19

sheets of tumor cells completely invading dermis?

Answer 19

merkel cell carcinoma

Question 20

metastatic tumors to the skin come most commonly from what organ in males? females?

Answer 20

• males: lung

- females: breast

Question 21

what is the sister mary joseph nodule?

Answer 21

umbilical nodule related to a visceral malignancy (stomach, pancreas)

Question 22

mammary paget’s disease is almost always associated with underlying ___________

Answer 22

mammary ductal carcinoma

Question 23

• pleomorphic spindle cell tumor with increased mitotic activity
• sun exposed area
• elderly
• firm solitary nodule with or without ulceration

Answer 23

AFX (atypical fibroxanthoma)

Question 24

what are the 3 settings for angiosarcoma?

Answer 24

• idiopathic
• lymphedema associated
• post-irradiation

Question 25

what are the 4 types of kaposi sarcoma?

Answer 25

• classic (endemic): distal extremities of mediterranean / Jewish populations
• AIDS related: skin and mucosal surfaces
• immunosuppression related
• african sub saharan