cvs23 Flashcards
confirmatory test for EBV
EBV nuclear antigen
EBV capsid antigen
mononucleosis like syndrome
congenital cmv
saliva
urinary
sexual contact
cmv in HIV
CREEP Colitis Retinitis Esophagitis ---- linear ulcers Encephalitis Pneumonitis
most common is retinitis
cmv inclusion
intra nuclear owl eyes
congenital cmv
choriretinitis (cotton wool exudates) seizures paraventricular calcifications microcephaly sensorineural deafness
HH6/7
Roseola
fever first then maculopapular rash
seizures
rash starts on trunk and spreads to extremities
HHV8
kaposci
CD4 <500
appear on feet and legs —- blue brownish dermal palque
can also appear on mucosa — GIT, face and lungs
lungs usually means LATE
histo in kaposci
spindle shaped
proliferation of ENDOTHELIUM + inflammation
RBC extravasate
lymphocyte predominance
what is kaposi commonly confused with
bartonell henslae
cat scratch
but this will have a stellate GRANULOMA with neutrophilic infilitration (bactera)
acyclovir
needs thymidine kinase to be phosphorylated
inibits DNA polymerase
leads to chain termination
acyclovir prodrug
valacyclovir
goood bioavailability
uses of acyclovir
HSV VZV EBV
what is bioavailibility
fraction of the drug that reaches systemic circulationin an unchanged manner
high first pass means
low systemic circulation conc
most drug is metabolised
bioavailibility formula
Area under curve (po) / AUC (IV)
loading dose
VD * Cp / f
rltnshp between loading dose and bioavalibility
high bio means low loading dose
ECF ICF
ECF = 1/3 = 14 ICF = 2/3 = 28
ECF is further divided into
plasma = 3 interstitium = 11
wich particals can go into the ICF
small uncharged lipophilic hydrophobic HIGHEST VOLUME OF D
small particles can have —- Vd
highest 42
they can be present in all layers
volume of distribution
D / C
half life
0.7 * Vd / Clearnce
absent hematotoxicity
acyclovir
crystalluria
SIGMA Sulfa drugs Indinavir Gancyclovir Methotrexate Acyclovir
agranulocytosis
CGMP carbamezapine, colchicine,clozapine gancyclovir---- inhib DNA polymerase methimazole---- inhib TP ptu ------ inhib TP and 5'deoidinase
seizures side effect of
BITE Bupropion / b6 INH / imipenem (cilastatin) Tramadol Enflurane
amantadine
landanosine
gancyclovir
foscarnet
foscarnet se
seizures
nephrotoxic
hypo hypercalcemia
hypo hyper phosphatemia
hypokalemia
hypomagnesiema
cidofovir
DNA P + RNA P no thymidyl kinase required CMV reitinits long t1/2 nephrotoxic
LEDIPASVIR
OMBITASVIR
NS5A
non structural protein RNA replication
SOFOSBUVIR
DASABUVIR
NS5B
chain termination
SIMEPREVIR
GRAZOPREVIR
NS3/ 4A
photosensitivity rashhhh
ortilstat
pancreatic lipase inhib
polygenic inheritence
HISTAGE Hypertension Ischemic heart Schizo Type 3 diabetes Androgernic alopecia Glaucoma Epilepsy
