cvs 20

Question 1

where do DNA viruses mostly replicate

Answer 1

Nucleus

Question 2

only SS DNA virus

Answer 2

parvo

Question 3

flehy papules central induration

umbilication

Answer 3

molluscum contagiosum

Question 4

non env DNA virus

Answer 4

PAPP
Parvo
Adeno
Papilloma
Polyoma

Question 5

Adenovirus can cause

Answer 5

Acut hem cystitis / acute myocarditis
Ds DNA / diarrhea
Eye pink conjunctivits / enteritis
Neumonia
O
V
I
R
URTI febrile pharyngitis
S

Question 6

Parvo

Answer 6

B19
SS DNA
non env
smallest DNA

Question 7

parvovirus in adults

Answer 7

acute / symmetric arthralgia and arthritis

hands / wrist / feet / knee

Question 8

parvo in children

Answer 8

slapped cheek
erythema infectiosum
fifth disease

Question 9

signs symptoms of 5th disease

Answer 9

incubation 1 - 2 weeks

lacy reticular rash — spares the nasolabial folds

Question 10

what causes the rash in 5th disease

Answer 10

immune complex IgM igG

Question 11

where does parvovirus replicate

Answer 11

in the erythrocyte precursor cells in boooone marrow

has an imp antigen ‘p antigen’ globoside

Question 12

P ag

Answer 12

parvovirus

Question 13

I CAM

Answer 13

rhinovirus

Question 14

CCR5/ CXCR4

Answer 14

HIV

Question 15

CD21

Answer 15

EBV

Question 16

integrin

Answer 16

CMV — heparan sulfate is another name for integrin

Question 17

nicotinic ach R

Answer 17

rabies

Question 18

what is heparan sulfate imp for

Answer 18

negative charge in kidney

keeps albumin in blood

Question 19

mucopolysaccharidosis

Answer 19

hunter vs hurler synd

Question 20

normocytic anemia <3 % CRC

Answer 20

UNDERPRODUCTION
aplastic anemia
CKD
early iron def anemia

Question 21

normocytic anemia >3 CRC %

Answer 21

means PERIPHERAL DESTRUCTION

divided into intrinsic vs extrinsic

Question 22

intrinsic defect (within RBC)

Answer 22

MAD
Membrane defects
-hereditary spherocytosis
-hereditary elliptocytosis
-PNH

Abnormal globin

• sickle cell disease
• Hemoglobin C disease

Deficient enzyme

• G6PD
• pyruvate kinase

Question 23

extrinsic defect

Answer 23

autoimmne hemolytic anemia
micro angiopathic hemolytic anemia
macro angipathuc
infectious ( MALARIA)

Question 24

site of erythropoesis

Answer 24

yolk salk — 3-8weeks
liver —— 6 - birth
spleen—– 10 - 28 w
bone marrow—— 18 w — adult

Question 25

if p53 is active

what are the steps downstream

Answer 25

induction of p21
inhibition of CDK
Rb is DE phosphorylated --- active
HOLDS E2F
halts cell cycle

Question 26

proapoptotic factors

Answer 26

BAX BAK BIM

Question 27

if p53 is inactive

what are the effects downstream

Answer 27

no induction of p21
no inhibition of CDK 
Cyclin CDK complex forms 
phosphorylates Rb ---- inactive form 
releases E2F
Cell cycle continues

Question 28

if Rb holds E2F what happens to cell cycle

Answer 28

halts cell cyc;e