Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

dr taher classes HK > cvs19 > Flashcards

cvs19 Flashcards

1
Q

rhabdo virus

A

bullet shaped

rabies (helical)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

transmission of rabies

A 
mostly bats 
fox
skunk
dogs
racoons
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

other diseases spread by bats

A

Histoplasma
Eebola
Rabies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what type of inclusion bodies seen in rabies

A

CYTOPLASMIC negri bodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

where do RNA viruses replicate

A

most in cytoplasm EXCEPT
influenza and retro

Replicates Inside nucleus ( R I )

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

DNA viruses replicate

A

in nucleus EXCEPT POX

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

rabies mannifestations

A 
hydrophobia 
aerophobia --- spasm of pharynx
agitation / anxiety
fever
malaise
myalgia
spasticity
autonomic instability
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Asc flaccid paralysis

A

rabies and guillane bare

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

desc flaccid paralysis

A

polio
diptheria
botulinism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

desc spastic paralysis

A

tetanus —- inhbition of glycine release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

prognosis of rabies

A

resp depression failure and death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

how does the virus enter body

A

enters neurons —- peripheral neurons —- dorsal root ganglion — ascends — replicates in brain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

retrograde transport within neuron by

A

DYENIN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

prophylactic vaccine for rabies given to

A

cave explorers
vets
labs (infected tissue)
ppl travelling to devlpng countries — DOGS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

beta proriolactone

A

used for culturing rabies vaccination

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

retroviruses

A

HTLV1

HIV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

HTLV1

A

adult t cell leukemia
lymphoma

mature CD4 T cells

Japanese/ caribbean/ west africa

skin lymhnodes bones (lytic bone lesions)
hepatosplenomegaly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what is the function of IL 1 interms of bone

A

increases osteoclas activating factor

HYPRCALCEMIA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

mycosis fungoides sezary syndrome

A

mature CD4 t cells
skin cutaneous T CELL LYMPHOMA

cancer cells aggrregate within epidermis —– intra epidermal aggregates of neoplastic cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

how does sezary sydnrome devlop

A

cancer cells within epidermis form micro abcess —- disseminate through blood —- t cell leukemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

HIV

A

replicates inside nucleus

polycystronic mRNA — 40 different types of proteins made

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

HIV makes multiple different types of proteins by which process

A

alternative splicing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

gag gene

A

capsid —- protein coat

matrix

24
Q

env gene

A

envelope glycoprotein gp 160

25
Q

gp 160 is broken down in

A

ER golgi —– 120 and 41

26
Q

pol gene

A

reverse transcriptase
aspartate proteinase
integrase

27
Q

CCR5 vs CCR4

A

CCR5 — presented by macrophages early

CXR4 — T cell late

28
Q

what glycoproetin is used for attachment

A

Gp 120

29
Q

fusion and entry

A

gp 41

chemokine associated receptor

30
Q

nucleoside RTI

A 
LADZ
Lamivudine 
Abacavir
Didanosine
Zidovudine
31
Q

CCR5 CXCR4 needed for

A

ENTRY

32
Q

what happens in HIV 2 infections

A

low levels of viral count
low risk of transmission
longer asymptomatic phase

33
Q

CCR5 homozygous mutation vs heterozygous

A

homo — immunity

hetero — slower onset of disease

34
Q

investigation for HIV

A

Ab immuno assay test

detects the capsid p24 ( made by gag gene)
increaesed sens + specificity

35
Q

what to do in case the immunoassay is negative

A

intermediate acute infection could be possible

NAT HIV1 required

36
Q

can u do immunoassay for neonates

A

NO wont detect antibodies

do RT PCR

37
Q

treatment for HIV

A

2 NRTI + integrase inhibitor

38
Q

zidovudine needs to be —– before it can function

A

phosphorylated

sometimes can also be incorp into genome —- chain termination!!

39
Q

how is resitance to zidocudine dvpd

A

pol gene mutation

rmmbe rpol gene —- trasncriptase

40
Q

how to decrease vertical transmission from mother to babies

A

zidovudine

nevirapine single dose can be given too

41
Q

SE of zidovudine

A 
BONE MARROW supp 
myalgia
myopathy 
lactic acidosis 
peripheral neuropathy
42
Q

how to treat bone marrow supp

A

G CSF —- filgrastim (for low wbc count)
GM CSF—-sargramostim (for low wbc count)

erythropoitin
darbopoitin

43
Q

thrombopoitin

A

ELTROMBOPAG—- -TPO rec agonist

ROMIPLASTIM —- TPO analog

OPRELVEKIN —- IL 11

44
Q

Aldesleukin

A

IL1

RCC and metastatic melanoma

45
Q

Lamivudine SE

A

LEAST TOXIC

active in HEP B

46
Q

Abacavir

A

allergy hypersensitivity HLA B5701 mutation

47
Q

Didanosine

A

PANCREATITIS / peripheral neuropathy

48
Q

dizoxide

A

decrease insulin production by opening K channels

49
Q

NNRTI

A

Dalaveridine
Efavirenz
Nevirapine

50
Q

vivid dreams or dysphoric dreams are caused by

A

efavirenz

51
Q

visual brightness increased by

A

IVABRIDINE
BR —bradycardia
I—- eye

52
Q

protease inhibtors

A

AVIRS

53
Q

increase creatinine kinas e

A

TEGRAVIRS

54
Q

allergic reaction at site of injection

A

enfuuuviritide

55
Q

drugs that cause crystalluria

A 
SIGMA
Sulfa
Indinavir
Gancyclovir
Methotrexate
Acyclovir

dr taher classes HK (24 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions