cvs 18 Flashcards
bithermal antibidy
IgG
mycoplasma and mononucleosis have these antibodies
IgM
which drugs can cause AIHA with IgG DONETH LANDSTEIN ab
pennicillin
2/3 penicillin
methyldopa
quinidine
antibodies against GP IIb IIIA
ITP
decrease exp of GP IIB IIIA
glanzman thrombocytopenia
direct combs test
antibody + RBC
indirect comb
normal RBC mix with serum of pt (AB)
RSV is most common cause of
bronchiolitis in babies
mannifestation and RF of bronchiolitis
nasal cong/distress/ flaring
tachypnea
wheezes/ crackles
RF——- prematurity —- resp failure
prophylaxiis for RSV
palivizumab —- fusion protein inhibtor
ribavirin (CHAIR mnemonic)
CLL mnemonic
HATS Hypogammaglobulinemia AIHA Transf to DLBL Small lymphocytic lymph
SMUDGE CELLS —- CD5 CD20
mechanism of Denosumab
mimics osteoprotegrin !! — acivates clast
TNF alpha can activate
Caspase
Measles mannifestation
rubeola
conjunctivitis
cough
coryza
RASH –maculopapular starts at head SPARES HANDS AND SOLES —- spreads down
rash taht includes palms soles
CARS Coxsackie A Rickestia ricketsie Syphilus
Sub acute sclerosing panecephalitis
myoclonus
caused by mutated or absent measles matrix protein —- prevents mature enveloped virion particle formation—- virus continously replicates
intranuclear inclusions in the oligodendrocytes
increased measles antibodies oligoclonal bands
dementia
what other conditions present wtih myoclonus
myoclonic epilepsy
SSPE
prion disease
opsoclonus myoclonus synd (neuroblastoma in children and SCLC in adults)
what type of lymphocytes are seen in encephalitis caused by measles
warthin finkeldey Giant cells — fused aggregated lymphocytes
immunocomp —- increased giant cell pneumonia
prophylaxis of measles
vit A
acute infection uses up vitamin A stores —- risk of keratitis and corneal ulceration
mumps (paramyxo)
POMPS parotitis orchitis---- sterility meningitis----- aseptic meningitis pancreatitis
RF of suppurative parotitis
obstruction —- calculus stone or tumors
sialolithiasis — stone in salivary duct
Parotid/ submandibular / sublingual nerves
977
nerves that have parasymp functionn
3 7 9 10
submandibular duct mostly has — stones
single stone —wharton duct
PAIN — pre post prandial
R/F for silolithiasis
dehydration
diurects
trauma
treatment for silolithiasis
warm compressions
NSAIDS
massage
sour candies
salivary gland tumors involves which salivary gland
PAROTID —- benign mostly
swelling and painless
painful wen involve facial nerve ( malignant)
less common tumors
sub mandibular and sublingual —- malignant
most common benign salivary gland tumor 1
PLEOMORPHIC ADENOMA
mixed tumor
stromal tissue - cartilage ( chondromyxoid)
epithelial tissue
angle of jaw
reover despite ressection — extend to capsule
most common benign SGT 2
warthin tumor
psammoma bodies — papilary cystadenoma lymphomatosum
benign cystic tumor with lymphocytes
germinal centers
can be bilateral too in 10%
smokers at risk for which salivary gland tumor
warthin
malignant SGT
mucoepidermal carcinoma
mucinous /squamous
involves facial nerve
other causes of suppurative parotitis
anticholinergic meds
intubation
post surgery
sjogern
pathogen for parotitis
staph a
anaerobes
choice of investigation parotitis
US/CT
aspiration
increased AMYLASE
Reo virus
12 segments Ds RNA virus
colti — colarado tick
rota
rota virus infects what
enterocytes villi of duodenum and prox jejunum —- BLUNTING OF VILLI
secretary crypt cells start prolif — na/k lost
brush border enzyme lost — disaccharide test
diarrhea in rota virus
non inflammatory
no leukocytes no RBCs
when to avoid rota virus vaccine
intussusception
SCID pts
