cvs 12 Flashcards
D actinomycin MOA
anti cancer
RNA polymeras II
cox 2 physiological and pathological function
PHYSIOLOGICAL
renal perfusion
tissue repair
PATHOLOGICAL
inflammation and pain
large vessel vasculitis
GTA
takayasu
medium vessel vasulitis
PAN
buerger
kawasaki
GTA most common in ?
females 60 yrs
branches of carotid artery
symptoms of GTA
fatigue fever malaise jaw claudication unilateral headache ischemic OPTIC NEUROPATHY polymyalgia rheumatica
diagnosis GTA
intimal layer thickening
FOCAL GRANULOMATOUS inflammation
segmental vasculitis so the wall looks normal
PMR
muscular pain and stiffness
shoulder and hip girdle
pain is WORSE IN MORNING and WORSE WITH activity
creatinine kinase NORMAL
steroids induced myopathy
progressive PROXIMAL musculoskeletal weakness
NO pain + atrophy of muscle
mostly involves LOWER extremity
creatinine kinase NORMAL
Polymyopathy (cd8)
dermatomyopathy (cd4)
proximal muscular weakness
arthritis can be +ve
dermatomyositis —- skin rash
Creatinine kinase is increased
hypothyroid myopathy
delayed reflexes
proximal muscular pain
creatinine kinase INCREASED
statin induced myopathy
proximal muscle pain and weakness
wks to months
CK iINCREASED
statins + fibrates SE
myopathy
statins + niacin
myopathy
fibrates + bile acid resins
gall stone
depression anxiety musculoskeletal pain and fatigue more than 3 months
multiple tender joints
fibromyalgia rheumatica
levels of ESR CRP in FMR
NORMAL
FMR age group
what form of exercise helps them
young females 20 -55
aerobics help them
txt for FMR
TCA —– amitryptilline imipramine desipramine clomipramine
SNRI —– duloxetine venlafaxine
txt for diabetic neuropathy
amitryptalline
duloxetine
which drug shd be avoided in elderly
AMITRYPTILLINE
