CSF Flashcards

1
Q

CSF functions (3)

A
  1. Supply nutrients to the CNS
  2. Remove metabolic waste
  3. Produce a mechanical barrier to cushion the brain and spinal cord against trauma
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2
Q

Lines the brain and spinal cord and are composed of three layers

A

Meninges

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3
Q

An outer layer, lines the skull and vertebral canal

A

Dura mater

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4
Q

Spider-like, filamentous inner membrane

A

Arachnoid mater

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5
Q

Innermost layer, lines the surface of the brain and spinal cord

A

Pia mater

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6
Q

in between arachnoid mater and pia mater; where CSF flow

A

Subarachnoid space

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7
Q

specific part of the brain that produces CSF

A

Choroid Plexus

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8
Q

The choroid plexuses are capillary networks that form the CSF from plasma by mechanisms of selective filtration under ________ and _______

A

hydrostatic pressure and active transport secretion.

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9
Q

T/F. The chemical composition of the CSF does resemble an ultrafiltrate of plasma

A

FALSE. The chemical composition of the CSF does NOT resemble an ultrafiltrate of plasma

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10
Q

rate of CSF production

A

20 ml/hr

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11
Q

A tightly fitting junctures structure of endothelial cells in the choroid plexus;
Protects the brain from chemicals and other substances circulating in the blood that can harm the brain tissue

A

Blood-Brain Barrier

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12
Q

Disruption of BBB allows _____, _____ and other chemicals to enter CSF

A

WBC; protein

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13
Q

CSF Collection (2)

A

Lumbar puncture/tap and cisternal puncture

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14
Q

Pressure before CSF is collected

A

between 90 and 180 mmHg

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15
Q

Volume collected when CSF is normal.

A

20 mL of specimen may be removed

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16
Q

On closing, the pressure should be between ____ and ____

A

10 and 30 mmHg

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17
Q

A marked decrease in pressure following this procedure suggests __________________ or ____________

A

cerebellar herniation or spinal cord compression

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18
Q

If the CSF pressure is less than or greater than normal 90-180 mmHg, only _____ is used

A

1-2 ml

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19
Q

Not more than _____ can be removed when the pressure is greater than ______

A

2 ml; 200 mmHg

20
Q

Normal CSF Volume
Adult:
Neonates:

A

Adult: 90 to 150ml (adults), 10 to 60ml (neonates)

21
Q

Tube #1 Lab Section and Storage Temp

A

Chemistry, Immunology, Serology; Freezer Temp

22
Q

Tube #2 Lab Section and Storage Temp

A

Microbiology; Room Temp

23
Q

Tube #3 Lab Section and Storage Temp

A

Hematology (Cell count), and Cytology studies; Refrigerator Temp

24
Q

Tube #4 Lab Section and Storage Temp

A

Microbiology (Better exclude skin contamination) or Serology (for additional serologic test)

25
Q

Order of section if 1 tube is used;

A

(Microbiology, Hematology, Chemistry/Serology)
Microbiology is first to avoid contamination

26
Q

T/F. Excess CSF should not be discarded and should be frozen until there is no further use of it.

A

Trueeeee

27
Q

T/F. Excess CSF should not be discarded and should be frozen until there is no further use of it.

A

Trueeeee

28
Q

Normal CSF Appearance

A

Crystal Clear

29
Q

Increase WBC that is greater than 200 /ul

A

Hazy

30
Q

Increase RBC that is greater than 400/ ul

A

Cloudy

31
Q

Presence of microorganism

A

Turbid

32
Q

Increase Proteins and Lipid

A

Milky

33
Q

Color of Xanthochromic sample

A

reddish to pinkish

34
Q

Slight amount of oxyhemoglobin color

A

Pink

35
Q

bilirubin traces color

A

Yellow

36
Q

Color in case of heavy hemolysis

A

Orange

37
Q

methemoglobin formation color

A

Brownish

38
Q

Greater than 6000 RBCs / ul due to: Traumatic tap or Intracranial hemorrhage / cerebral hemorrhage

A

Bloody / grossly bloody

39
Q

Radiographic contrast dye Appearance

A

Oily

40
Q

Protein and clotting factors
Meningitis, Froin’s syndrome appearance

A

Clotted

41
Q

Tubercular meningitis appearance

A

Pellicle

42
Q

Tube 1 has the highest blood followed by Tube 2 and Tube 3

A

Traumatic Tap

43
Q

Equal distribution of blood in 3 tubes

A

Intracranial Hemorrhage

44
Q

Matchy
True of Intracranial Hemorrhage
1. Presence of clot
2. Xanthochromic after 1 hour
3. D-dimer test positive
4. Absent Erythrophages

a. 1&2 b. 2&4 c. 1,2,&3 d. all e. none

A

only 3 is true :D.

Presence of clot and absent erythro is traumatic tap
Xanthocromic after 2 HOURS

45
Q

Matchy
1. No clot formation
2. Clear Supernatant
3. Supernatant will be Xanthochromic after 2 hours
4. Presence of clot

a. Traumatic Tap
b. Intracranial Hemorrhage

A
  1. b
  2. a
  3. b
  4. a
46
Q

Matchy
1. Presence of Erythrophage
2. D-dimer negative
3. D-dimer Positive
4. Absence of Erythropage

a. Traumatic Tap
b. Intracranial Hemorrhage

A
  1. b
  2. a
  3. b
  4. a