CELLS AND INCLUSIONS SEEN IN SYNOVIAL FLUID Flashcards
Polymorphonuclear leukocyte
Neutrophil
Neutrophil SIGNIFICANCE
Bacterial sepsis, Crystal induced inflammation
Mononuclear leukocyte
Lymphocyte
Lymphocyte SIGNIFICANCE
Non-septic inflammation
Large mononuclear leukocyte, may be vacuolated
Macrophage
Similar to macrophage, but may be multinucleated resembling a mesothelial cell
Synovial lining cell
Neutrophil containing characteristic ingested “Round homogenous body”
LE cell
LE cell significance
Lupus erythematosus
Vacuolated macrophage with ingested neutrophils
Reiter cell
Reiter cell significance
Reiter syndrome
Non-specific inflammation
Neutrophil with dark cytoplasmic granules containing immune complexes
RA cell
(Ragocyte)
RA cell (Ragocyte) significance
Rheumatoid arthritis
Immunologic inflammation
Large multinucleated cells
Cartilage cells
Cartilage cells significance
Osteoarthritis
Macroscopically resembles polished rice
Microscopically shows collagen and fibrin
They are fragments of degenerating proliferative synovial cells or microinfarcted synovium
Rice bodies
Rice bodies significance
Tuberculosis, septic and rheumatoid arthritis
Refractile intracellular and extracellular globules stain with Sudan
Fat droplets
Fat droplets significance
Traumatic injury
RBCs normal value for synovial fluid
<2000/ul
WBCs normal value for synovial fluid
< 200 / ul
Percentage for synovial fluid
Monocyte and macrophages %
Neutrophils
Lymphocytes
Monocyte and macrophages 65 %
Neutrophils <25 %
Lymphocytes <15 %
An eosinophil of greater than 2 %is associated with allergic disease with
arthritis, hemorrhagic joint effusion, Lyme disease, parasitic arthritis, RA, and tubercular arthritis