Crossword 5 - Core Clinical Biochemistry

Question 1

Patients with primary adrenal cortical insufficiency caused by adrenal dysgenesis, adrenal destruction or autoimmune
adrenalitis can show a triad of postural hypotension, hyponatraemia and what?

Answer 1

Hyperpigmentation

Question 2

When bone density decreases there is a decrease in the rate of bone formation compared to the rate of bone…?

Answer 2

Resorption

Question 3

The net effect of parathyroid hormone is to do what to serum calcium levels?

Answer 3

Increase

Question 4

The vast majority of primary pituitary tumours are what type of tumour?

Answer 4

Adenoma

Question 5

Regarding the autoimmune chronic inflammatory disorder of the thyroid associated with diffuse enlargement of the gland and thyroid autoantibodies, what is there an 80 fold increased risk of?

Answer 5

Lymphoma

Question 6

A growth hormone secreting pituitary tumour in children can cause gigantism and what does it cause in adults?

Answer 6

Acromegaly

Question 7

The most common tumour of the islets of Langerhans causes what abnormality in biochemical blood testing that can lead to sweating, anxiety, palpitations and many other signs and symptoms?

Answer 7

Hypoglycaemia

Question 8

HbA1c is also known as ________ haemoglobin?

Answer 8

Glycated

Question 9

In multinodular goitre what can a dominant nodule be clinically mistaken for which could lead to unnecessary surgical resection?

Answer 9

Carcinoma

Question 10

After autoimmune destruction of the beta cells in the islets of Langerhans, the ensuing disease is often of rapid onset and presents with which particular metabolic syndrome?

Answer 10

Ketoacidosis

Question 11

What autoimmune process in the thyroid results in clinical hyperthyroidism and diffuse hyperplasia of the follicular epithelium? _ _ _ _ _ _ disease

Answer 11

Grave’s

Question 12

The adult adrenal medullary tumour that can cause paroxysmal features including hypertension, panic attacks and headaches does so by episodic release of what?

Answer 12

Catecholamines

Question 13

In patients with low albumin, the total calcium can be low even though the calcium level is normal. One way to get a more accurate picture is to measure what type of calcium with a blood gas analyser?

Answer 13

Ionised

Question 14

The commonest type of thyroid carcinoma is more common in females, can be secondary to radiation and can occur at quite young ages. What sort of carcinoma is it?

Answer 14

Papillary