Crossword 2: Core Clinical Immunology Flashcards
There are 2 types of rejection that are antibody mediated. The 3rd type is the T cell dependent immune process where the transplanted tissue may lose function 7-10 days after transplant. What is the 3rd type of rejection called? Acute _ _ _ _ _ _ _ _ Rejection
Cellular
A 45 year old woman has a red rash over her cheeks, worse in the sun, ulcers on the roof of her mouth, painful but not particularly swollen joints and hair loss. She then develops symptoms and investigations indicating renal dysfunction. A renal biopsy shows inflamed glomeruli (glomerulonephritis). Deposition of what is most likely to have caused the renal inflammation? Immune _ _ _ _ _ _ _ _ _
Complexes
To reduce rejection episodes / increase the chances of graft survival what serological or molecular test can be done? _ _ _ typing
HLA
What is the “H” of MHC?
Histocompatibility
What is the type of immunity that has no memory, responds quickly (hours to days) and lasts only a short time?
Innate
What is the name of the cells that are part of the innate immune system, that can both destroy cells infected by some viruses but also can stimulate the adaptive immune response? _ _ cells
NK cells
What is the therapeutic effect called that may lead to immunopotentiation, immunosuppression, or induction of immunological tolerance? (16)
Immunomodulation
Common clinical manifestations of adverse reactions to food include those in the respiratory tract, skin and which other main organ system?
GI
A person is exposed to an innocuous antigen and develops an immune response (ie is pre-sensitised). The person subsequently develops an undesirable, damaging, discomfort-producing or even fatal reaction by their immune system. What is the type of reaction described?
Allergic
What is the process called where the adaptive immune system recognises and targets the body’s own molecules, cells and tissues instead of infectious agents and malignant cells?
Autoimmunity
The atopic triad includes a skin condition, an airway condition and a nasopharyngeal condition. What is the nasal congestion with oedema, mucus and nasal polyps called? Allergic _ _ _ _ _ _ _ _
Rhinitis
What is the process where there are seemingly spontaneous attacks of systemic inflammation with no demonstrable source of infection as a precipitating cause, an absence of high-titre autoantibodies and antigen specific autoreactive T cells and no evidence of auto-antigenic exposure?
Autoinflammation
A person has a reaction to poison ivy. A biopsy of the skin lesions show granulomas. What type of hypersensitivity reaction does this scenario describe?
Delayed
What is the name of the paediatric emergency where there is a defect or absence of a critical T cell molecule which can be cured by haemopoietic stem cell transplant? Severe _ _ _ _ _ _ _ _ Immunodeficiency
Combined
A 45 year old woman has a red rash over her cheeks, worse in the sun, ulcers on the roof of her mouth, painful but not particularly swollen joints and hair loss. She then develops symptoms and investigations indicating renal dysfunction. A renal biopsy shows inflamed glomeruli (glomerulonephritis). Serological testing shows a positive ANA. What is the likely diagnosis?
SLE
