Cranial Nerves Flashcards
What are the 3 regions of the brainstem?
Midbrain
Pons
Medulla
What are nuclei in the brain?
Collections of the cell bodies of nerve fibres
How many cranial nerves arise from the brain itself (forebrain)?
2
How many cranial nerves arise from the midbrain?
2
How many cranial nerves arise from the pons?
4
How many cranial nerves arise from the medlla?
4
What is the mneumonic to help remember how many cranial nerves arise from different regions of the brain/brainstem?
2, 2, 4, 4
2 arise from forebrain
2 arise from midbrain
4 arise from pons
4 arise from medulla
Which 2 cranial nerves arise from the forebrain?
Olfactory and optic
CN I and II
How many cranial nerves arise from the brainstem?
10 (III- XII)
What kind of information does the olfactory nerve transmit?
Special sensory
What is the function of the olfactory nerve?
Smell
What is the route and relation of the olfactory nerve to the CNS?
Olfactory nerve -> cribiform foramina -> olfactory bulb -> olfactory tracts -> forebrain
What is anosmia?
The absence of the sense of smell
What skull base cavity does the olfactory nerve (CN I) travel through?
Crimiform foramina of cribiform plate
What is the target tissue of the olfactory nerve?
Mucosal membrane roof of nasal cavity
How is the olfactory nerve tested?
Enquiry about sense of smell, smelling salts
What kind of information does the optic nerve transmit?
Special sensory
What skull base cavity does the optic nerve (CN II) pass through?
Optic canal
What does the anatomical course of the optic nerve describe?
Transmission of special sensory information from the retina to the primary visual cortex
What happens at the optic chiasm?
Optic nerves cross over
What is the point at which the optic nerve enters the retina?
Optic disc
Why can the optic nerve swell due to raised ICP?
Carry extension of meninges - can see evidence of raised ICP on fundoscopy as a swollen optic disc
What would lesions involving the retina or the optic nerve cause?
Visual disturbance affecting only one eye
Where is the primary visual cortex?
Occipital lobe
Why do pituitary tumours cause bilateral visual symptoms?
Compress optic chiasm - both eyes affected
What does the pituitary gland lie in close proximity to?
Optic chiasm (in middle cranial fossa)
What would a patient with bitemporal hemianopia describe?
Tunnel vision (visual defect affecting the peripheral vision in both eyes)
In which bone is the optic chiasm?
Sphenoid
Which two cranial nerves arise from the midbrain?
Oculomotor and Trochlear
CN III and IV
What kind of information does the oculomotor nerve (CN III) transmit?
Motor and autonomic (parasympathetic)
What motor function does the oculomotor nerve serve?
Innervates most extraocular muscles
What do the autonomic components of the oculomotor nerve do?
Supplies sphincter pupillae (pupil) and ciliary muscle (lens)
What are the functions of the oculomotor nerve?
Eye movements, pupil constriction, eyelid opening
What foramen does the oculomotor nerve (CN III) pass through?
Superior orbital fissure
Describe the route of the oculomotor nerve
From the midbrain, runs through lateral wall of cavernous sinus, exits through the SOF, into orbit
What are the three main causes of an oculomotor nerve lesion?
1) Increasing ICP - uncus can squish tentorium cerebelli and thus CN III which is in close proximity
2) Aneurysm of the posterior cerebral artery
3) Cavernous sinus infection or trauma
Why can cavernous sinus infection cause damage to CN III?
Oculomotor nerve runs through the lateral wall of the cavernous sinus
What are the clinical signs of CN III injury?
Oculomotor nerve lesion
1) ptosis - due to paralysis of levator pulpabrae superioris
2) eyeball is down and out - paralysis of rectus muscles and inferior oblique
3) dilated pupil - due to unopposed action of dilator pupillae (can’t costrict)
How is CN III tested?
Inspection of eyelid and pupils, eye movements, pupillary light reflexes
What kind of information is transmitted by the trochlear nerve (CN IV)?
Motor
What is the only nerve to emerge from the dorsal aspect of the brainstem?
Trochlear (CN IV)
Which cranial nerve has the longest intracranial course?
Trochlear (CN IV)
Describe the course of the trochlear nerve
Arises from posterior aspect of midbrain, runs within the subarachnoid space, moves along lateral wall of cavernous sinus, enters orbit of eye via the SOF
Which foramen does the trochlear nerve pass through?
Superior orbital fissure
What single muscle does the trochlear nerve innervate?
Superior oblique
What is the function of the trochlear nerve?
Innervates one extraorbital muscle - superior oblique
What is the overall action of the superior oblique?
Depress and intort the eyeball
How is the trochlear nerve examined?
By testing movements of the eye (eg patient asked to follow a point with their eyes without moving their head)
What is diplopia?
Double vision
How does trochlear nerve palsy present?
Vertical diplopia - exacerbated by looking down and in
Patients can also develop a head tilt away from affected side