COVID Flashcards
Virus
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)
Disease
COVID-19
SARS-CoV-2 is a _ virus
RNA
The nucleocapsid protein
binds with RNA genome to make helical ribonucleoprotein
The membrane protein
transmembrane envelope protein
determines shape of viral envelope
Envelope protein
interacts with M protein to form viral envelope
important for infectivity
Spike protein
binds to host cell receptors to faculitate entry into host cells
targeted by host neutralizing antibodies
Where did SARS-CoV-2 come from
88% shared linage with bat genome
How does SARS-CoV-2 enter cells
S protein activated by TMPRSS2 and ACE2 cleaves receptor to faculiate binding
virus enters via endocytosis, releases RNA, and replicates using cell machinery
virions cause rapid progression of disease
what happens during infection
entry and replication
antigen presentation
cellular immunity
humoral immunity
cytokine storm
manifestations of sever COVID-19
CNS
cardiovascular disease
lung disease
kidney failure
hypercoagulable disease
hyperinflammatory state
The incubation period during which people are asymptomatic
about 5 days
Common symptoms associated with COVID-19
fever
dry cough
shortness of breath
loss of tast and smell
type of therapy depends on
severity of infection
dexamethasone is NOT recommended for _
mild disease
