Cough and Hemoptysis Flashcards
Forced expulsive maneuver usually against a closed glottis, whih is associated sound
cough
Cough pellets
Broncholiths
Initiation of cough
Voluntary cough -cortex
Reflexive cough - vagus nerve and its branches
Most sensitive sites for initiating cough
larynx and tracheobronhial tree, esp. carina and branching points
Phases of cough Production
- Inspiratory
- Compressive/ Glottic Closure
- Expulsive (Expiratory or explosive)
- recovery
Inspiratory phase of coughing
1st phase
2.5 L
negative flow rate
Compressive/ Glottic cllosure
2nd phase of production
Zero flow rate
Pressure builds up, to as high as 300 mmHg
Positive intrathoracic pressure
Expulsive (Expiratory or explosive)
3rd Phase 1st cough sound heard Growing, constant, decreasing sub-phases Positive flow rate Pressure is highest 120 to 160kph large pressure differential
Recovery
4th phase of coughing
Restorative inspiration
Which phase is not critical to effective coughing?
Glottic clossure
Initiation of cough
- Inflammatory or mechanical changes in the airways
- Polymodal Sensosy nerve receptros
- Rapid and large changes in lung volumes
- Psychological factors
Exaggerated response to harmless or mildly irritating stimuli
Cough sensor plasticity
Which nerves are involved in both the efferent and afferent limbs of the cough reflex?
Phrenic and Vagus
Medullary cough pattern generatory
Nucleus tractus solitarius
Dual primary sensory neuron model of cough induction
C fibers - chemical irritants
Mechanoreceptors - sense punctate mechanical forces
Compose most of the bronchopulmonary vagal afferent nerves, with terminals in and around the mucosa surface of the airways
Unmyelinated C-fiber nociceptors
Sensitive to bradykinin and activators of the ion channels
Unmyelinated C fibers
TRPV1
Capsaicin, protons
TRPVA1
Ozone, spices, mustard, wasabi-allyl isothiocyanate
Mechanically sensitive “cough receptors”
beneath the epithelium in the large airways
Relative insensitive to most chemical mediators
Include Widdicombe cough receptors and lung stretch receptors
Include Widdicombe cough receptors and lung stretch receptors -
Rapidly adapting receptors (RARs) and slowly adapting receptors (SARs)
The major afferent pathway
Vagus nerve
Stimuli triggering the vagus nerve
Ear, pharynx, larynx, trachea, carina, large intrapulmonary bronchi, heart, pericardium, esophagus
Involuntary cough appears to be initiated only from
vagal innervation of the airways
Airway afferent nerve fibers originate in the ________-
nodose and jugular ganglia
Airway afferents are stimulated by irritants or inflammatory mediators via _______?
activation of G protein coupled receptors
Factors contibuting to cough Inefficiency
- Altered cough mechanics
- altered mucous rheology
- altered mucociliary function
Altered cough mechanics
- Expiratory muscle weakness
- Inspiratory muscle weakness
- Abdominal wall muscle weakness
Altered mucous rheology
Adhesiveness
Cohesiveness
Composition of Normal Mucus
95% water
3% mucin
1% lipids
<0.3% DNA
Confers viscosity and elasticity
Mucin
Liquid-like propertythat resists flow -stickness
Viscosity
Solid-like capacity to store energy that moves or deforms the fluid - stringiness
Elasticity
MUC genes
20 human MUC genes
9 expressed in the human respiratory tract
membrane tethered Mucin
MUC 1, MCU 4, MUC 16
Only 3 are classic gel-forming mucins
MUC 2 , MUC 5AC, MUC5B
MUC produced mostly at proximal airways by goblet cells
MUC5AC