Contraindications/Black Box Warnings - Pain/GU

Question 1

Baclofen contraindications

Answer 1

Hypersensitivity

Question 2

Buprenorphine/Naloxone contraindications

Answer 2

Hypersensitivity

Question 3

Carisoprodol contraindications

Answer 3

Hypersensitivity; acute intermittent porphyria

Question 4

Celecoxib contraindications

Answer 4

Asthma, urticaria, or allergic-type reaction following aspirin or other NSAID administration; CABG surgery, treatment of perioperative pain, hypersensitivity to sulfonamides

Question 5

Codeine/Acetaminophen contraindications

Answer 5

Hypersensitivity, use in age < 12 y of age, use in age 12-18 y postoperatively after tonsillectomy

Question 6

Cyclobenzaprine contraindications

Answer 6

Hypersensitivity, concomitant MAOI use, heart failure, acute coronary phase of AMI, heart block, hyperthyroidism

Question 7

Diclofenac contraindications

Answer 7

Hypersensitivity to diclofenac, concurrent ketorolac use, asthma, allergic type reaction following other NSAID use, CABG

Question 8

Etodolac contraindications

Answer 8

Hypersensitivity; concurrent use of ketorolac or pentoxifylline; allergic-type reaction following NSAID; CABG surgery, treatment of perioperative pain

Question 9

Fentanyl Transdermal contraindications

Answer 9

Acute or postoperative pain, bronchial asthma, hypersensitivity to fentanyl, mild or intermittent pain, opioid nontolerant patient, paralytic ileus

Question 10

Hydrocodone (w/o acetaminophen) contraindications

Answer 10

Hypersensitivity, paralytic ileus, respiratory depression, severe asthma

Question 11

Ibuprofen contraindications

Answer 11

Hypersensitivity, concurrent use with ketorolac or pentoxifylline; asthma, urticaria, or allergic-type reaction following aspirin or other NSAID administration; CABG surgery, treatment of perioperative pain

Question 12

Indomethacin contraindications

Answer 12

Hypersensitivity, concurrent use with ketorolac or pentoxifylline; asthma, urticaria, or allergic-type reaction following aspirin or other NSAID administration; CABG surgery, treatment of perioperative pain

Question 13

Lidocaine contraindications

Answer 13

Hypersensitivity

Question 14

Meloxicam contraindications

Answer 14

Hypersensitivity; concurrent ketorolac, pentoxifylline use, asthma, allergic-type reaction following other NSAID use, CABG

Question 15

Methadone contraindications

Answer 15

Bronchial asthma, hypersensitivity to opioids, paralytic ileus, respiratory depression, hypercarbia

Question 16

Methocarbamol contraindications

Answer 16

Hypersensitivity

Question 17

Morphine contraindications

Answer 17

Hypersensitivity to opioids, acute or severe asthma, paralytic ileus, respiratory depression, GI obstruction, concurrent use or use within 14 days of MAOI

Question 18

Nabumetone contraindications

Answer 18

Hypersensitivity to nabumetone, other NSAIDs, aspirin, or sulfonamides; concurrent use of ketorolac, or pentoxifylline; asthma, CABG surgery

Question 19

Naproxen contraindications

Answer 19

Hypersensitivity to naproxen, other NSAIDs, aspirin or sulfonamides; asthma or allergic-type reaction following aspirin or other NSAID administration, CABG surgery, treatment of perioperative pain

Question 20

Oxycodone contraindications

Answer 20

Hypersensitivity to oxycodone or other opioids, asthma, paralytic ileus, respiratory depression, hypercarbia

Question 21

Pentosan contraindications

Answer 21

Hypersensitivity

Question 22

Tramadol contraindications

Answer 22

Hypersensitivity to tramadol or other opioids, paralytic ileus, respiratory depression, bronchial asthma, age <12 y, hypercapnia, MAOI use or use within last 14 d

Question 23

Darifenacin contraindications

Answer 23

Hypersensitivity to darifenacin, gastric retention, glaucoma, urinary retention

Question 24

Dutasteride contraindications

Answer 24

Hypersensitivity to dutasteride, pregnancy, use in children

Question 25

Finasteride contraindications

Answer 25

Hypersensitivity to finasteride, pregnancy, or use in children

Question 26

Mirabegron contraindications

Answer 26

Hypersensitivity

Question 27

Oxybutynin contraindications

Answer 27

Hypersensitivity to oxybutynin, gastric retention, glaucoma, urinary retention

Question 28

Sildenafil contraindications

Answer 28

Hypersensitivity to phosphodiesterase inhibitors, concurrent nitrates, concurrent HIV protease inhibitors when used for treating pulmonary HTN, concurrent guanylate cyclase stimulators

Question 29

Solifenacin contraindications

Answer 29

Hypersensitivity to solifenacin, gastric retention, uncontrolled glaucoma, urinary retention

Question 30

Tadalafil contraindications

Answer 30

Hypersensitivity to phosphodiesterase inhibitors, concurrent nitrates, concurrent guanylate cyclase stimulators

Question 31

Tamsulosin contraindications

Answer 31

Hypersensitivity

Question 32

Tolterodine contraindications

Answer 32

Hypersensitivity to tolterodine or fesoterodine, gastric retention, uncontrolled narrow-angle glaucoma, urinary retention

Question 33

Vardenafil contraindications

Answer 33

Hypersensitivity to PDE inhibitors, concurrent use of nitrates and guanylate cyclase stimulators

Question 34

Phenazopyridine contraindications

Answer 34

Hypersensitivity and renal failure

Question 35

Baclofen BBW

Answer 35

Avoid abrupt discontinuation of oral or intrathecal product

Question 36

Celecoxib BBW

Answer 36

GI toxicity, cardiotoxicity, CABG

Question 37

Codeine/Acetaminophen BBW

Answer 37

Hepatotoxicity; Children who are CYP2D6 ultrarapid metabolizers; serious risks of misuse, abuse, addiction, overdose, and death; concurrent use with benzodiazepines; immediate release only, serious risk of misuse, accidental ingestion, neonatal opioid withdrawal syndrome

Question 38

Diclofenac BBW

Answer 38

Cardiovascular, GI risk, CABG

Question 39

Etodolac BBW

Answer 39

Cardiovascular and GI risk

Question 40

Fentanyl Transdermal BBW

Answer 40

Addiction, CYP 3A4/5 interactions, respiratory depression, fatalities in children, formulations not interchangeable, fever, care with disposal, REMS program, concurrent use with benzodiazepines or other CNS depressants, neonatal withdrawal, medication errors, heat exposure

Question 41

Hydrocodone (w/o acetaminophen) BBW

Answer 41

Addiction, abuse, misuse, REMS, respiratory depression, accidental ingestion, neonatal opioid withdrawal, alcohol, CYP3A4/5 interactions, hepatotoxicity, concurrent use with benzodiazepines

Question 42

Ibuprofen BBW

Answer 42

Cardiovascular events, GI toxicity, CABG

Question 43

Indomethacin BBW

Answer 43

Cardiovascular events, GI toxicity, CABG

Question 44

Meloxicam BBW

Answer 44

Cardiovascular thrombotic events, serious GI bleeding and perforation, CABG

Question 45

Methadone BBW

Answer 45

Accidental ingestion; addiction, abuse, and misuse; QTc prolongation; respiratory depression; concurrent use with benzodiazepines; REMS; neonatal opioid withdrawal; conditions for use in opioid addiction; CYP interactions

Question 46

Morphine BBW

Answer 46

Ethanol, addiction, abuse, and misuse, REMS, respiratory depression, neonatal opioid withdrawal, accidental ingestion, concurrent use with benzodiazepines, medication errors

Question 47

Nabumetone BBW

Answer 47

Thrombotic events; GI bleeding

Question 48

Naproxen BBW

Answer 48

Cardiovascular and GI risk; thrombotic events

Question 49

Oxycodone BBW

Answer 49

Addiction, abuse potential; REMS, respiratory depression, accidental ingestion, neonatal withdrawal, CYP3A4/5 interaction, concurrent use with benzodiazepines, medication errors with oral solution

Question 50

Tramadol BBW

Answer 50

Addiction, abuse, misuse, REMS, respiratory depression, accidental ingestions, CYP2D6 in children, neonatal withdrawal syndrome, drug interactions, concurrent benzodiazepines, medication errors, drug interactions with P450s